We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14- monocytes showed a more activated profile upon in vitro infection with T. cruzi than CD14+ monocytes. Our findings suggest that T- genotype is associated with susceptibility to develop Chagas dilated cardiomyopathy, likely linked to the T. cruzi-induced inflammatory profile of CD14- monocytes.

中文翻译：

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CD14基因型和CD14 +和CD14-细胞功能二分法与活化的免疫应答和南美锥虫病扩张型心肌病的发展有关

我们旨在研究CD14 -260C / T（rs2569190）多态性与Chagas心肌病的关系，以及感染克氏锥虫后CD14 +和CD14-单核细胞的功能特征。我们观察到与低CD14表达有关的T基因型（无等位基因-260T）与Chagas病的扩张型心肌病之间存在关联。此外，我们观察到，在体外感染克氏锥虫后，CD14-单核细胞比CD14 +单核细胞显示出更多的活化特征。我们的研究结果表明，T型基因型与发展南美锥虫病（Chagas）扩张型心肌病的易感性有关，这可能与克鲁格氏菌诱导的CD14单核细胞的炎性特征有关。