当前位置: X-MOL 学术Synthesis › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Recent Progress towards Organocatalyzed Asymmetric (Hetero)Arene Formation
Synthesis ( IF 2.2 ) Pub Date : 2020-10-28 , DOI: 10.1055/s-0040-1707327
Tingshun Zhu , Ke Xu , Ziyuan Wang


Abstract

Owing to the importance of arene moieties in organic chemistry, methods for arene construction attract great attention. Besides the traditional substitution strategy from pre-existing arenes, the straightforward formation of arene cores can also provide significant shortcuts towards a wide array of target molecules with different substitution patterns. Among direct arene formation reactions, applying environmentally benign organocatalysis to access arene moieties continues to attract increasing attention. This short review provides a brief summary of recent progress on organocatalyzed de novo (hetero)arene formation and applications in enantioselective synthesis.

1 Introduction

2 Arene Formation with Non-Covalent Organocatalysts

2.1 Arene Formation with Acid Organocatalysts

2.2 Arene Formation with Base Organocatalysts

2.3 Arene Formation with Hydrogen-Bonding Organocatalysts

3 Arene Formation with Covalent Organocatalysts

3.1 Arene Formation with Lewis Base Organocatalysts

3.1.1 Arene Formation with Secondary Amine Organocatalysts

3.1.2 Arene Formation with Tertiary Amine, Tertiary Phosphine and Sulfide Organocatalysts

3.1.3 Arene Formation with N-Heterocyclic Carbene Organocatalysts

3.2 Arene Formation with Lewis Acid Organocatalysts

4 Conclusion



Publication History

Received: 30 August 2020

Accepted after revision: 15 September 2020

Publication Date:
28 October 2020 (online)

© 2020. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany



中文翻译:

有机催化不对称(杂)芳烃形成的最新进展


摘要

由于芳烃部分在有机化学中的重要性,因此芳烃构建方法引起了极大的关注。除了来自现有芳烃的传统取代策略外,芳烃核心的直接形成还可以为大量具有不同取代模式的靶分子提供重要的捷径。在直接的芳烃形成反应中,将对环境有益的有机催化应用于芳烃部分的应用继续引起越来越多的关注。这篇简短的评论简要概述了有机催化从头(杂)芳烃的形成及其在对映选择性合成中的应用的最新进展。

1引言

2与非共价有机催化剂形成的芳烃

2.1与酸性有机催化剂的芳烃形成

2.2与基础有机催化剂的芳烃形成

2.3结合氢的有机催化剂形成的芳烃

3与共价有机催化剂形成的芳烃

3.1与路易斯碱有机催化剂的芳烃形成

3.1.1与仲胺有机催化剂形成的芳烃

3.1.2与叔胺,叔膦和硫化物有机催化剂形成的芳烃

3.1.3 N-杂环碳有机催化剂形成的芳烃

3.2路易斯酸有机催化剂形成的芳烃

4。结论



出版历史

收到:2020年8月30日

修订后接受:2020年9月15日

发布日期:
2020年10月28日(在线)

©2020年。Thieme。版权所有

Georg Thieme Verlag
KGRüdigerstraße14,70469斯图加特,德国

更新日期:2020-10-30
down
wechat
bug