Hosts with compromised or naive immune systems, such as individuals living with HIV/AIDS, transplant recipients, and fetuses, are at the highest risk for complications from cytomegalovirus (CMV) infection. Despite substantial progress in prevention, diagnostics, and treatment, CMV continues to negatively impact both solid-organ transplant (SOT) and hematologic cell transplant (HCT) recipients. In this article, we summarize important developments in the field over the past 10 years and highlight new approaches and remaining challenges to the optimal control of CMV infection and disease in transplant settings.

中文翻译：

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移植中巨细胞病毒感染预防、诊断和管理的进展与挑战

免疫系统受损或幼稚的宿主，例如 HIV/AIDS 感染者、移植受者和胎儿，发生巨细胞病毒 (CMV) 感染并发症的风险最高。尽管在预防、诊断和治疗方面取得了重大进展，但 CMV 继续对实体器官移植 (SOT) 和血液细胞移植 (HCT) 受者产生负面影响。在本文中，我们总结了过去 10 年该领域的重要进展，并重点介绍了在移植环境中最佳控制 CMV 感染和疾病的新方法和剩余挑战。