Calcium signaling is essential for different physiological processes. Indeed, some immunodeficiency diseases, such as cardiovascular abnormalities, are associated with Ca²⁺‐release‐activated Ca²⁺(CRAC) channel dysfunction. Therefore, understanding the gating and regulation of the CRAC channel is vital for exploring its biological functions. Jun Huo and Hao Dong summarize recent progress in CRAC channel gating and its regulation from structural biology studies, biochemical and electrophysiological measurements, and molecular modeling. Integration between experiments and computations has further deepened our understanding of this important cell membrane channel. (DOI: 10.1002/bip.23392)

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钙信号对于不同的生理过程至关重要。确实，一些免疫缺陷疾病，例如心血管异常，与Ca ²⁺释放激活的Ca ²⁺（CRAC）通道功能障碍有关。因此，了解CRAC通道的门控和调节对于探索其生物学功能至关重要。Jun Huo和Hao Dong总结了CRAC通道门控及其在结构生物学研究，生化和电生理测量以及分子建模方面的最新进展。实验与计算之间的集成进一步加深了我们对这一重要细胞膜通道的理解。（DOI：10.1002 / bip.23392）