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A hexanuclear Nd (III) complex derived from a Schiff base with significant antitumor and antifungal activity
Applied Organometallic Chemistry ( IF 3.7 ) Pub Date : 2020-10-30 , DOI: 10.1002/aoc.6081 Lijuan Hua 1 , Wenge Li 1 , Yan Chen 1 , Kai Liang 1 , He Cai 1 , Jing Wang 1 , Siyu Wang 1 , Tianyue Yin 1 , Lili Liang 1
Applied Organometallic Chemistry ( IF 3.7 ) Pub Date : 2020-10-30 , DOI: 10.1002/aoc.6081 Lijuan Hua 1 , Wenge Li 1 , Yan Chen 1 , Kai Liang 1 , He Cai 1 , Jing Wang 1 , Siyu Wang 1 , Tianyue Yin 1 , Lili Liang 1
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A hexanuclear Nd (III) complex {[Nd6(HL)2L2X2(NO3)8(EtOH)6]·(EtOH)(H2O)3} (H2L = 2,3‐dihydroxybenzaldehyde‐4‐aminoantipyrine; H2X = 2,3‐dihydroxy benzaldehyde) has been designed, synthesized, and evaluated for antitumor and antifungal activity. Single‐crystal X‐ray diffraction analysis indicates Nd (III) complex has a trinuclear cluster structure, which further forms a hexanuclear monomer through two bridging ligands L2−. There are π–π interactions and a lot of intramolecular hydrogen bonds between monomers. Antitumor activity of Nd (III) complex against human hepatocellular carcinoma SMMC‐7721 cells has been studied by 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyltetrazolium bromide (MTT) assay and morphology observation. The IC50 value of Nd (III) complex ranges from 4.02 to 4.85 μM, much smaller than that of clinical drug (gemcitabin) and free ligand (H2L), which is consistent with its high inhibition rate of 90%. Inhibitory zone of 26 mm reveals the significant antifungal activity of Nd (III) complex against Candida albicans.
中文翻译：
源自席夫碱的六核Nd（III）配合物，具有显着的抗肿瘤和抗真菌活性
六核Nd（III）络合物{[Nd 6（HL）2 L 2 X 2（NO 3）8（EtOH）6 ]·（EtOH）（H 2 O）3 }（H 2 L = 2,3-二羟基苯甲醛‐4-氨基安替比林; H 2 X = 2,3-二羟基苯甲醛）已被设计，合成并评估了其抗肿瘤和抗真菌活性。X射线单晶衍射分析表明Nd（III）配合物具有三核簇结构，该结构通过两个桥接配体L 2−进一步形成六核单体。单体之间存在π-π相互作用和许多分子内氢键。Nd（III）复合物对人类肝细胞癌SMMC-7721细胞的抗肿瘤活性已通过3-（4,5-二甲基-2-噻唑基）-2-5,5-二苯基四唑溴化物（MTT）分析和形态观察进行了研究。Nd（III）配合物的IC 50值为4.02至4.85μM，远小于临床药物（gemcitabin）和游离配体（H 2 L），这与其90％的高抑制率是一致的。26 mm的抑制区显示Nd（III）复合物对白色念珠菌具有显着的抗真菌活性。
更新日期：2020-10-30
中文翻译：
源自席夫碱的六核Nd（III）配合物，具有显着的抗肿瘤和抗真菌活性
六核Nd（III）络合物{[Nd 6（HL）2 L 2 X 2（NO 3）8（EtOH）6 ]·（EtOH）（H 2 O）3 }（H 2 L = 2,3-二羟基苯甲醛‐4-氨基安替比林; H 2 X = 2,3-二羟基苯甲醛）已被设计，合成并评估了其抗肿瘤和抗真菌活性。X射线单晶衍射分析表明Nd（III）配合物具有三核簇结构，该结构通过两个桥接配体L 2−进一步形成六核单体。单体之间存在π-π相互作用和许多分子内氢键。Nd（III）复合物对人类肝细胞癌SMMC-7721细胞的抗肿瘤活性已通过3-（4,5-二甲基-2-噻唑基）-2-5,5-二苯基四唑溴化物（MTT）分析和形态观察进行了研究。Nd（III）配合物的IC 50值为4.02至4.85μM，远小于临床药物（gemcitabin）和游离配体（H 2 L），这与其90％的高抑制率是一致的。26 mm的抑制区显示Nd（III）复合物对白色念珠菌具有显着的抗真菌活性。
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