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Looking back at multi drug resistance (MDR) research and ten mistakes to be avoided when writing about ABC transporters in MDR.
FEBS Letters ( IF 3.0 ) Pub Date : 2020-11-21 , DOI: 10.1002/1873-3468.13972
Piet Borst 1
Affiliation  

This paper presents a personal, selective, and sometimes critical retrospective of the history of ABC transporters in multidrug resistance (MDR) of cancer cells, overrepresenting discoveries of some early pioneers, long forgotten, and highlights of research in Amsterdam, mainly focussing on discoveries made with disruptions of ABC genes in mice (KO mice) and on the role of ABC transporters in causing drug resistance in a mouse model of mammary cancer. The history is complemented by a list of erroneous concepts often found in papers and grant applications submitted anno 2020.

中文翻译:

回顾多药耐药性 (MDR) 研究以及撰写 MDR 中的 ABC 转运蛋白时应避免的十个错误。

这篇论文对 ABC 转运蛋白在癌细胞多药耐药 (MDR) 中的历史进行了个人的、选择性的、有时是批判性的回顾,过度代表了一些早期先驱的发现,长期被遗忘,以及阿姆斯特丹的研究亮点,主要集中在所做的发现ABC 基因在小鼠(KO 小鼠)中的破坏以及 ABC 转运蛋白在乳腺癌小鼠模型中引起耐药性的作用。2020 年提交的论文和拨款申请中经常出现的错误概念清单补充了这段历史。
更新日期:2020-11-21
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