Recently, SARS‐CoV‐2 has been identified as the causative factor of viral infection called COVID‐19 that belongs to the zoonotic beta coronavirus family known to cause respiratory disorders or viral pneumonia, followed by an extensive attack on organs that express angiotensin‐converting enzyme II (ACE2). Human transmission of this virus occurs via respiratory droplets from symptomatic and asymptomatic patients, which are released into the environment after sneezing or coughing. These droplets are capable of staying in the air as aerosols or surfaces and can be transmitted to persons through inhalation or contact with contaminated surfaces. Thus, there is an urgent need for advanced theranostic solutions to control the spread of COVID‐19 infection. The development of such fit‐for‐purpose technologies hinges on a proper understanding of the transmission, incubation, and structural characteristics of the virus in the external environment and within the host. Hence, this article describes the development of an intrinsic model to describe the incubation characteristics of the virus under varying environmental factors. It also discusses on the evaluation of SARS‐CoV‐2 structural nucleocapsid protein properties via computational approaches to generate high‐affinity binding probes for effective diagnosis and targeted treatment applications by specific targeting of viruses. In addition, this article provides useful insights on the transmission behavior of the virus and creates new opportunities for theranostics development.

中文翻译：

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通过 N 蛋白计算表征对 SARS-CoV-2 传播和治疗诊断发展进行生物物理分析


最近，SARS-CoV-2 已被确定为称为 COVID-19 的病毒感染的致病因素，该病毒属于人畜共患 β 冠状病毒家族，已知会引起呼吸系统疾病或病毒性肺炎，随后对表达血管紧张素转换的器官进行广泛攻击酶 II (ACE2)。这种病毒通过有症状和无症状患者的呼吸道飞沫传播，这些飞沫在打喷嚏或咳嗽后释放到环境中。这些液滴能够以气溶胶或表面的形式停留在空气中，并可以通过吸入或接触受污染的表面传播给人类。因此，迫切需要先进的治疗诊断解决方案来控制 COVID-19 感染的传播。这种适合用途的技术的开发取决于对病毒在外部环境和宿主体内的传播、孵化和结构特征的正确理解。因此，本文描述了一种内在模型的开发，以描述病毒在不同环境因素下的孵化特征。它还讨论了通过计算方法评估 SARS-CoV-2 结构核衣壳蛋白特性，以生成高亲和力结合探针，通过特异性靶向病毒进行有效诊断和靶向治疗应用。此外，本文提供了有关病毒传播行为的有用见解，并为治疗诊断学的发展创造了新的机会。