Recent Advances in Asymmetric Organomulticatalysis,Advanced Synthesis & Catalysis

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Recent Advances in Asymmetric Organomulticatalysis
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-10-28 , DOI: 10.1002/adsc.202000961
Xiao Xiao _{1,

2} , Bing‐Xuan Shao _{1,

2} , Yin‐Jie Lu _{1,

2} , Qian‐Qian Cao _{1,

2} , Chun‐Nian Xia ₁ , Fen‐Er Chen _{1,

3,

4}

Affiliation

Asymmetric multi‐catalysis, designed to mimic catalytic processes in nature, is a powerful instrument to fulfil fascinating transformations. As a result, this area of research has attracted considerable interests within chemistry communities. Although there are numerous reviews involving multi‐catalysis, reviews describing asymmetric organomulticatalysis remain rare. Taking into consideration that organocatalysts possess the superiorities of effortless availability, inexpensiveness, hypotoxicity, facile handling and hyposensitivity to moisture and oxygen, they have definite advantage in their own distinct modes of activation when utilized in multi‐catalytic reactions. Organomulticatalysis refers to the synthetic strategies of modular combination of organo‐catalyzed reactions into one synthetic operation with minimum workup or change in conditions. It is apparent that a variety reports utilizing the concept of enantioselective organomulticatalysis have substantially surfaced in the past few years. Hence, it is indispensable to succinctly present all such reports by means of disclosing the mechanistic analysis, as well as the challenges and issues associated in the development of the asymmetric catalytic system. Additionally, this review will introduce some of the unsettled conundrums and possible innovations in this field.

中文翻译：

不对称有机多催化的最新进展

设计用来模拟自然界中的催化过程的不对称多催化是完成引人入胜的转化的有力工具。结果，该研究领域在化学界引起了相当大的兴趣。尽管有许多涉及多催化的评论，但描述不对称有机多催化的评论仍然很少。考虑到有机催化剂具有容易获得，廉价，低毒，易处理以及对湿气和氧气不敏感的优势，当用于多催化反应时，它们在各自独特的活化方式方面具有明显优势。有机多催化是指将有机催化反应模块化组合到一个合成操作中且所需的后处理或条件变化最少的合成策略。显然，在过去几年中，利用对映选择性有机多催化概念的各种报道已基本浮出水面。因此，必不可少的是通过公开机理分析以及不对称催化体系发展中的挑战和问题，简洁地呈现所有此类报告。此外，本文将介绍该领域一些尚未解决的难题和可能的创新。

更新日期：2020-10-28

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