Free‐radical Initialized Cyclization of 2‐(3‐Arylpropioloyl)benzaldehydes with Toluene Derivatives: Access to Benzylated 1,4‐Naphthoquinones via Copper‐Catalyzed Cascade Reaction,Advanced Synthesis & Catalysis

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Free‐radical Initialized Cyclization of 2‐(3‐Arylpropioloyl)benzaldehydes with Toluene Derivatives: Access to Benzylated 1,4‐Naphthoquinones via Copper‐Catalyzed Cascade Reaction
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-10-28 , DOI: 10.1002/adsc.202000975
Bingbin Zhu ₁ , Hang Han ₂ , Wei‐Ke Su ₁ , Chuanming Yu ₂ , Xinpeng Jiang ₂

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A copper‐catalyzed cyclization reaction of 2‐(3‐arylpropioloyl)benzaldehydes was developed, leading to benzylated 1,4‐naphthoquinones via radical‐triggered cascade cyclization. This example of an acylbenzylation involving internal alkynes could be carried out with a broad substrate scope and wide functional group tolerance.

中文翻译：

甲苯衍生物对2-（3-芳丙基丙氧基）苯甲醛的自由基引发的环化反应：通过铜催化的级联反应获得苯甲酰化的1,4-萘醌

开发了铜催化的2-（3-芳基丙氧基）苯甲醛的环化反应，该反应通过自由基触发的级联环化反应生成苄基的1,4-萘醌。涉及内部炔烃的酰基苄基化反应的该实例可以在宽的底物范围和宽的官能团耐受性下进行。

更新日期：2020-10-28

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