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Biosafety Level 2 cabinet UV‐C light exposure of sports antidoping human urine samples does not affect the stability of selected prohibited substances
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-10-29 , DOI: 10.1002/dta.2954 Sven Voss 1 , Wadha Abushreeda 1 , Ariadni Vonaparti 1 , Aisha Al‐Wahaibi 1 , Noora Al‐Sowaidi 1 , Ibrahim Al‐Mohannadi 1 , Souhila Mahieddine 1 , Safa Khelifi 1 , Sofia Salama 1 , Amal Saleh 1 , Maryam Al‐Mohannadi 1 , Wesal El‐Saftawy 1 , Khalifa Al‐Hamad 1 , Ahmad Nofal 1 , Najib Dbes 1 , Rodrigo Aguilera 1 , Mohammed Al Maadheed 1 , Costas Georgakopoulos 1
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-10-29 , DOI: 10.1002/dta.2954 Sven Voss 1 , Wadha Abushreeda 1 , Ariadni Vonaparti 1 , Aisha Al‐Wahaibi 1 , Noora Al‐Sowaidi 1 , Ibrahim Al‐Mohannadi 1 , Souhila Mahieddine 1 , Safa Khelifi 1 , Sofia Salama 1 , Amal Saleh 1 , Maryam Al‐Mohannadi 1 , Wesal El‐Saftawy 1 , Khalifa Al‐Hamad 1 , Ahmad Nofal 1 , Najib Dbes 1 , Rodrigo Aguilera 1 , Mohammed Al Maadheed 1 , Costas Georgakopoulos 1
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The current study examined the stability of several antidoping prohibited substances analytes in urine after 15‐min exposure to UV‐C light in a Biosafety Level 2 cabinet. The urine matrices were exposed within the original antidoping bottles with the aim to destroy DNA/RNA and possible SARS CoV‐2. The analytes small molecules Phase I and Phase II metabolites and peptides, in total 444, endogenous, internal standards, and prohibited substances, pH, and specific gravity in urine were studied. The accredited analytical methods were used by Anti‐Doping Laboratory Qatar for the comparison of data of the same urine samples analyzed with and without UV‐C exposure. In the study conditions, no problems of stability were detected in the substances spiked in the urine samples exposed in the UV‐C irradiation.
中文翻译：
运动安全性人类尿液样本的生物安全级别2柜UV-C曝光不会影响所选违禁物质的稳定性
当前的研究在生物安全等级2的橱柜中暴露了15分钟的UV-C光后，检查了尿液中几种反掺杂违禁物质分析物的稳定性。尿液基质暴露在原始的反兴奋剂瓶中，目的是破坏DNA / RNA和可能的SARS CoV-2。研究人员分析了总共444种分析物的小分子I和II期代谢物和多肽，内源性，内标物以及尿液中的禁用物质，pH和比重。卡塔尔反兴奋剂实验室使用了认可的分析方法，比较了有和没有暴露于UV-C的相同尿液样品的数据。在研究条件下，在UV-C照射下暴露的尿液样品中加标的物质中未发现稳定性问题。
更新日期：2020-10-29
中文翻译：
运动安全性人类尿液样本的生物安全级别2柜UV-C曝光不会影响所选违禁物质的稳定性
当前的研究在生物安全等级2的橱柜中暴露了15分钟的UV-C光后，检查了尿液中几种反掺杂违禁物质分析物的稳定性。尿液基质暴露在原始的反兴奋剂瓶中，目的是破坏DNA / RNA和可能的SARS CoV-2。研究人员分析了总共444种分析物的小分子I和II期代谢物和多肽，内源性，内标物以及尿液中的禁用物质，pH和比重。卡塔尔反兴奋剂实验室使用了认可的分析方法，比较了有和没有暴露于UV-C的相同尿液样品的数据。在研究条件下，在UV-C照射下暴露的尿液样品中加标的物质中未发现稳定性问题。
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