Thiol‐ene click reactions of pentaerythritol tetrakis(3‐mercaptopropionate) with pentaerythritol tetraacrylate and trimethylolpropane triacrylate were used to prepare polymeric degradable networks. The structure and properties of these networks were studied using Fourier‐transform infrared and Raman spectroscopy, thermal gravimetric analysis and scanning electron microscopy. Degradation of these materials was evaluated in different media including phosphate buffer with and without esterase as well as in oxidative environment with hydrogen peroxide. Exposure of the samples to these media results in their degradation. Slow hydrolytic degradation was observed in phosphate buffer and it was not accelerated by the presence of an enzyme. Faster degradation is observed in solutions of hydrogen peroxide. The mechanisms of this degradation are discussed.

中文翻译：

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使用硫醇-烯“点击”化学与季戊四醇四（3-巯基丙酸酯）和三/四丙烯酸酯合成水解和氧化响应网络

季戊四醇四（3-巯基丙酸酯）与季戊四醇四丙烯酸酯和三羟甲基丙烷三丙烯酸酯的硫醇-烯点击反应用于制备聚合物可降解网络。使用傅里叶变换红外光谱和拉曼光谱、热重分析和扫描电子显微镜研究了这些网络的结构和性质。这些材料的降解在不同的介质中进行了评估，包括含有和不含酯酶的磷酸盐缓冲液，以及在含有过氧化氢的氧化环境中。将样品暴露于这些介质会导致其降解。在磷酸盐缓冲液中观察到缓慢的水解降解，并且不会因酶的存在而加速。在过氧化氢溶液中观察到更快的降解。讨论了这种降解的机制。