Total hip arthroplasty uses commercial devices that combine different types of biomaterials. Among them, metals, ceramics and metal oxides can be used either in the prosthesis itself or in the cement used to anchor them in the bone. Over time, all of these materials can wear out and release particles that accumulate in the periprosthetic tissues or can migrate away. We used histology blocks from 15 patients (5 titanium metallosis, 5 alumina prostheses, 5 with altered methacrylic cement) to perform a microCT study and compare it with conventional histology data. An EDS - SM analysis was done to characterize the atomic nature of the materials involved. A morphometric analysis was also performed in 3D to count the particles and assess their density and size. The metallic particles appeared to be the largest and the ceramic particles the finest. However, microCT could not reveal the wear particles of radiolucent biomaterials such as polyethylene and the very fine zirconia particles from cement fragmentation. MicroCT analysis can reveal the extent of the accumulation of these debris in the periprosthetic tissues. This article is protected by copyright. All rights reserved.

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通过显微计算机断层扫描分析髋关节假体释放的磨损碎片

全髋关节置换术使用结合不同类型生物材料的商业设备。其中，金属、陶瓷和金属氧化物既可用于假体本身，也可用于将它们固定在骨中的水泥。随着时间的推移，所有这些材料都会磨损并释放出积聚在假体周围组织中的颗粒，或者可以迁移出去。我们使用来自 15 名患者的组织学块（5 名钛金属、5 名氧化铝假体、5 名使用改变的甲基丙烯酸水泥）进行显微 CT 研究并将其与传统组织学数据进行比较。进行了 EDS - SM 分析以表征所涉及材料的原子性质。还在 3D 中进行了形态测量分析，以对颗粒进行计数并评估它们的密度和尺寸。金属颗粒似乎最大，陶瓷颗粒最细。然而，显微CT 无法揭示聚乙烯等射线可透生物材料的磨损颗粒和水泥碎裂产生的非常细的氧化锆颗粒。MicroCT 分析可以揭示这些碎片在假体周围组织中的积累程度。本文受版权保护。版权所有。