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Significance of the Ability to Differentiate Emotional Prosodies for the Early Diagnosis and Prognostic Prediction of Mild Hypoxic‐Ischemic Encephalopathy in Neonates
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2020-11-17 , DOI: 10.1002/jdn.10074 Lili Liu 1 , Yuehang Geng 1 , Yun Cui 1 , Yanxia Zhou 1 , Guoyu Sun 1 , Cheng Peng 1 , Rui Zhang 1 , Yuanpei Ma 1 , Yanan Liu 1 , Chufan Sun 1 , Xinlin Hou 1 , Junya Chen 1
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2020-11-17 , DOI: 10.1002/jdn.10074 Lili Liu 1 , Yuehang Geng 1 , Yun Cui 1 , Yanxia Zhou 1 , Guoyu Sun 1 , Cheng Peng 1 , Rui Zhang 1 , Yuanpei Ma 1 , Yanan Liu 1 , Chufan Sun 1 , Xinlin Hou 1 , Junya Chen 1
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BACKGROUND
Perinatal brain injury affects around 300,000 neonates in China each year, early diagnosis and active intervention are also crucial for timely treatment and better prognoses. As hearing is the earliest as well as the most sensitive sense to develop in neonates, we propose that the ability to differentiate among different emotional prosodies may differ between neonates with and without brain injuries. METHODS
We enrolled full-term neonates admitted to the neonatology department of Peking University First Hospital from January 2016 to December 2016, conducted functional near-infrared spectroscopy (fNIRS) monitoring within 24h of admission, and analyzed changes in oxyhemoglobin (ΔHbO2 ) and deoxyhemoglobin (ΔHb) to study the ability of neonates to differentiate among emotional prosodies. The neonates were followed-up to 36 months for neurological outcome evaluation. RESULTS AND CONCLUSIONS
We found that neonates showed the early ability to differentiate among emotional prosodies, responding most sensitively to positive emotions, and this ability may have been impaired following brain injury.
更新日期:2020-11-17