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Detailed immune monitoring of a pregnant woman with critical Covid-19
Journal of Reproductive Immunology ( IF 2.9 ) Pub Date : 2020-10-29 , DOI: 10.1016/j.jri.2020.103243
N A du Fossé 1 , K Bronsgeest 1 , M S Arbous 2 , M Zlei 3 , S K Myeni 4 , M Kikkert 2 , Jjm van Dongen 3 , Fjt Staal 3 , Mlp van der Hoorn 1 , T van den Akker 1
Affiliation  

A primigravid woman with Covid-19 related respiratory insufficiency was admitted into a tertiary Intensive Care Unit at 23 3/7 weeks’ gestation. Highly sensitive flow cytometry of peripheral leukocytes indicated significantly suppressed naïve T- and B-cell compartments. The suppressed immune cell responses led us keep the initially started administration of corticosteroids for fetal and maternal indication at a low dose. After three weeks her B-cell response peaked, SARS-CoV-2 was cleared and clinical improvement ensued a week later. At 28 weeks’ gestation, a son of 1570 g was born by cesarean section. She was extubated two days postpartum and discharged from hospital 5.5 weeks postpartum.



中文翻译:

对患有严重 Covid-19 的孕妇进行详细的免疫监测

一名患有 Covid-19 相关呼吸功能不全的初产妇在妊娠 23 3/7 周时被送入三级重症监护病房。外周血白细胞的高灵敏度流式细胞术表明,幼稚 T 细胞和 B 细胞区室受到显着抑制。抑制的免疫细胞反应导致我们将最初开始的用于胎儿和母体适应症的皮质类固醇维持在低剂量。三周后,她的 B 细胞反应达到峰值,SARS-CoV-2 被清除,一周后临床症状出现改善。孕28周剖宫产1570g儿子。她在产后两天拔管,并在产后 5.5 周后出院。

更新日期:2020-11-04
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