Modified mycotoxins in foodstuffs, animal feed, and herbal medicines present considerable threats to human and animal health. The diversity and wide distribution make their presence unavoidable and difficult to control. The European Food Safety Authority also recommends setting group health-based guidance values for modified mycotoxins. Significant changes in physicochemical properties of modified mycotoxins, making their detection difficult using routine analytical methods. Given the lack of commercial analysis standards and maximum limit regulations, there remains a great challenge for accurate identification and quantitation of modified mycotoxins. This review first summarizes the latest knowledge regarding target and non-target qualitative and quantitative analysis for modified mycotoxins comprehensively. In addition, this review elucidates the major transformation mechanisms of modified mycotoxins. Overall, this work lays the foundation for improving their early detection, consumer warning, safety evaluation, and control of modified mycotoxins.

食品，动物饲料和草药中经过修饰的霉菌毒素对人类和动物健康构成了巨大威胁。多样性和广泛分布使它们的存在不可避免并且难以控制。欧洲食品安全局还建议为真菌毒素设定基于团体健康的指导值。修饰的霉菌毒素的理化性质发生重大变化，使其难以使用常规分析方法进行检测。鉴于缺乏商业分析标准和最高限量规定，对于准确鉴定和定量修饰的霉菌毒素仍存在巨大挑战。这篇综述首先全面总结了有关修饰真菌毒素的目标和非目标定性和定量分析的最新知识。此外，这篇综述阐明了修饰的霉菌毒素的主要转化机制。总的来说，这项工作为改善其早期发现，消费者警告，安全性评估以及对改性真菌毒素的控制奠定了基础。