Phytochemicals extracted from natural sources are widely studied for many applications, including the prevention of diseases and functional foods. In this context, passion fruit by-products (PFBP) can play an important role in obtaining these compounds. This work aimed to concentrate PFBP extracts from supercritical fluid extraction (SFE) (fixed at 40 °C and 35 MPa) in δ-tocotrienol, β/γ-tocotrienol, squalene, and carotenoids using a homemade fractionation system with two separator vessels. Integrated extraction and fractionation (SFE-SFF) were performed at 17−25 MPa and 50−80 °C. An economic evaluation simulated a pilot-scale process, resulting in a cost of US$ 277–384/kg extract for the most concentrated fraction (F2). Two SFE-SFF conditions were able to concentrate squalene in about 5.2 times in the last fraction of the process (F3). In contrast, the proposed integrated process did not seem promising to concentrate carotenoids, thus other fractionation methods should be investigated.

从天然来源提取的植物化学物质已被广泛研究用于许多应用，包括预防疾病和功能性食品。在这种情况下，百香果副产物（PFBP）在获得这些化合物中可以发挥重要作用。这项工作旨在使用带有两个分离器的自制分馏系统将超临界流体萃取（SFE）（固定在40°C和35 MPa下）的PFBP萃取物浓缩在δ-生育三烯酚，β/γ-生育三烯酚，角鲨烯和类胡萝卜素中。综合萃取和分馏（SFE-SFF）在17-25 MPa和50-80°C下进行。一项经济评估模拟了中试规模的过程，结果是，最浓缩的部分（F2）的提取成本为277-384美元/千克。在该过程的最后一部分中，两个SFE-SFF条件能够将角鲨烯浓缩约5.2倍（F3）。