In this study, we report a solid-phase synthesis of 1,3-thiazole based peptidomimetic molecules. The key reaction step is dehydrative cyclization of thiourea resin intermediate with 2-bromo-1-(3-nitrophenyl)ethanone to afford 1,3-thiazole core with benzyl-nitro group attached. Further modification of the nitro group with peptide elongations yielded resin-bound N-benzyl-1,3-thiazole derivatives with short peptide chains at C4 and C5 positions. Cleavage from the resin delivered compounds in moderate yields. Synthesized compounds had high purities (>97%).

中文翻译：

---

二肽基链修饰的1,3-噻唑文库的固相平行合成

在这项研究中，我们报告了基于1,3-噻唑的拟肽分子的固相合成。关键的反应步骤是将硫脲树脂中间体与2-溴-1-（3-硝基苯基）乙酮进行脱水环化反应，制得带有苄基硝基的1,3-噻唑核。用肽延伸物进一步修饰硝基，得到在C4和C5位置具有短肽链的树脂结合的N-苄基-1,3-噻唑衍生物。从树脂上切下以中等产率递送化合物。合成的化合物具有高纯度（> 97％）。