Malaria a mosquito-borne disease caused by Plasmodium remains to be a main global burden despite concerted efforts to eliminate it. While diverse control strategies have been put in place for mosquito-borne diseases, vector control continues to be a critical component in infection prevention. Vector control majorly focuses on the eradication of mosquitoes using a variety of chemical insecticides that includes organochlorides, carbamates, organophosphates, and pyrethroids. The use of conventional insecticide-based as mosquito control strategies poses several challenges such as the widespread development of insecticide resistance, environmental damage concerns, and effects on non-target organisms. These challenges create a demand for the development and use of alternative pest control strategies that are sustainable, safer, and environmentally friendly to mosquito vector management. This review provides insight into alternative sustainable interventions for mosquito vector control in the form of biorational pesticides. Biorational pesticides are pesticides that have little or no effect on humans and environments and include entomopathogenic microorganisms, insect growth regulators, and endosymbiotic bacteria. It also puts into perspective their environmental impacts, benefits, and challenges. Further, countries like Sri Lanka, that are certified as malaria free by World Health Organization (WHO) incorporated the use of entomopathogenic bacteria, insect growth regulators and larvivorous fish in their national vector control programs leading to the successful elimination of malaria in 2016. We therefore highlight success stories of the countries that have implemented these interventions bringing out the lessons for countries that are battling malaria epidemics.

疟疾是由疟原虫引起的蚊媒疾病尽管人们齐心协力消除了这一负担，但仍将是全球主要负担。尽管已经针对蚊媒疾病采取了多种控制策略，但媒介控制仍然是预防感染的关键组成部分。病媒控制主要集中在使用各种化学杀虫剂（包括有机氯化物，氨基甲酸酯，有机磷酸盐和拟除虫菊酯）消灭蚊子。传统的基于杀虫剂的蚊子控制策略的使用带来了一些挑战，例如广泛发展的杀虫剂抗药性，对环境的破坏以及对非目标生物的影响。这些挑战对开发和使用替代性害虫控制策略提出了要求，这些策略对于蚊媒的管理是可持续，安全和环境友好的。这篇综述提供了对以生物合理农药形式控制蚊媒的替代性可持续干预措施的见解。生物合理农药是对人类和环境几乎没有影响的农药，包括昆虫病原微生物，昆虫生长调节剂和共生细菌。它还透视了它们对环境的影响，利益和挑战。此外，像斯里兰卡这样被世界卫生组织（WHO）认证为无疟疾的国家，将昆虫病原菌，昆虫生长调节剂和幼虫鱼的使用纳入了其国家病媒控制计划中，从而在2016年成功消除了疟疾。