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Addition of propolis to milk improves lactating lamb’s growth: effect on antimicrobial, antioxidant and immune responses in animals
Small Ruminant Research ( IF 1.6 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.smallrumres.2020.106265
Bruno G.O. Cécere , Aleksandro S. da Silva , Vitor L. Molosse , Davi F. Alba , Karoline W. Leal , Gilneia da Rosa , Wanderson A.B. Pereira , Anielen D. da Silva , Maria Rosa C. Schetinger , Aniela P. Kempka , Aline Nunes , Marcelo Maraschin , Denise N. Araújo , Guilherme Luiz Deolindo , Marcelo Vedovatto

Abstract This study evaluated the effects of propolis extract, mixed in milk, on growth as well as on antimicrobial, antioxidant and immune responses in lactating lambs. Thirty-six Lacaune lambs [males; 7.0 ± 1.2 day (d) of age; 4.9 ± 0.80 kg of body weight (BW)] were assigned to the following groups: T0, T150, T200 and T250, representing 0, 150, 200, and 250 μL of propolis/kg of BW/d, respectively. All dosages (T150, T200, and T250) significantly increased weight gain (P = 0.01) with the greatest increase observed in T150 lambs (0.174, 0.244, 0.213, and 0.200 kg/d for T0, T150, T200, and T250, respectively). On regression analysis, the optimal dosage for improving weight gain was 137 μL of propolis/kg of BW/d. All dosage increased (P = 0.05) serum concentrations of total protein on d 10, but only T250 increased it on d 30. Only T150 increased (P = 0.02) the serum concentration of albumin on d 10, and all dosages increased it on d 30. The T200 tended to increase (P = 0.09) the serum concentration of immunoglobulin A, and T150 and T200 tended to increase (P = 0.09) the concentration of immunoglobulins heavy-chain. The T200 and T250 increased the concentration of transferrin on d 10 and only T250 increased it on d 42 (P = 0.01). All dosages increased (P = 0.04) the serum concentration of glucose. No effects were detected (P ≥ 0.11) for globulin, IgG light-chain, ceruloplasmin, urea, triglycerides, cholesterol, aspartate aminotransferase, or gamma-glutamyltranspeptidase. All dosage decreased (P = 0.01) the serum concentration of reactive oxygen species on d 30; however, only T150 and T200 decreased it on d 42, and the greatest reduction was observed for T150. All dosages increased (P = 0.01) nitric oxide levels on 30; however, only T150 and T200 increased them on d 42. All dosage decreased (P = 0.01) the concentration of superoxide dismutase. All dosages increased (P = 0.01) the concentration of non-protein thiols and protein thiols, with the greatest effects detected for T250. All dosages decreased (P = 0.01) counts of E. coli and total coliform counts in feces, with the greatest effects observed for T150 and T200. Taken together, the data suggest that addition of propolis to milk increased growth as well as antimicrobial, antioxidant, and immune responses in lactating lambs. The greatest effects were observed for the dosage of 150 μL of propolis/kg of BW/d.

中文翻译:

在牛奶中添加蜂胶可改善哺乳期羔羊的生长:对动物抗菌、抗氧化和免疫反应的影响

摘要 本研究评估了蜂胶提取物混合在牛奶中对哺乳期羔羊的生长以及抗菌、抗氧化和免疫反应的影响。三十六只 Lacaune 羔羊 [雄性;7.0 ± 1.2 天 (d) 日龄;4.9 ± 0.80 kg 体重 (BW)] 被分配到以下组:T0、T150、T200 和 T250,分别代表 0、150、200 和 250 μL 蜂胶/kg BW/d。所有剂量(T150、T200 和 T250)均显着增加体重增加(P = 0.01),在 T150 羔羊中观察到的增加最大(T0、T150、T200 和 T250 分别为 0.174、0.244、0.213 和 0.200 kg/d) )。在回归分析中,改善体重增加的最佳剂量是 137 μL 蜂胶/kg BW/d。所有剂量在第 10 天增加(P = 0.05)血清总蛋白浓度,但只有 T250 在第 30 天增加。只有T150在第10天增加(P=0.02)血清白蛋白浓度,所有剂量在第30天增加。T200倾向于增加(P=0.09)免疫球蛋白A血清浓度,T150和T200倾向于增加(P = 0.09) 免疫球蛋白重链的浓度。T200 和 T250 在第 10 天增加了转铁蛋白的浓度,只有 T250 在第 42 天增加了它(P = 0.01)。所有剂量都增加(P = 0.04)葡萄糖的血清浓度。未检测到对球蛋白、IgG 轻链、血浆铜蓝蛋白、尿素、甘油三酯、胆固醇、天冬氨酸氨基转移酶或 γ-谷氨酰转肽酶的影响(P ≥ 0.11)。所有剂量均降低(P = 0.01)第30天血清活性氧浓度;然而,只有 T150 和 T200 在第 42 天降低了它,T150 的降低幅度最大。所有剂量均在 30 时增加(P = 0.01)一氧化氮水平;然而,只有 T150 和 T200 在第 42 天增加了它们。所有剂量都降低了(P = 0.01)超氧化物歧化酶的浓度。所有剂量都增加了 (P = 0.01) 非蛋白质硫醇和蛋白质硫醇的浓度,对 T250 检测到的影响最大。所有剂量均降低 (P = 0.01) 大肠杆菌计数和粪便中的总大肠菌群计数,对 T150 和 T200 观察到的影响最大。总之,数据表明在牛奶中添加蜂胶可促进哺乳羔羊的生长以及抗菌、抗氧化和免疫反应。对于 150 μL 蜂胶/kg BW/d 的剂量观察到最大的影响。01)超氧化物歧化酶的浓度。所有剂量都增加了 (P = 0.01) 非蛋白质硫醇和蛋白质硫醇的浓度,对 T250 检测到的影响最大。所有剂量均降低 (P = 0.01) 大肠杆菌计数和粪便中的总大肠菌群计数,对 T150 和 T200 观察到的影响最大。总之,数据表明在牛奶中添加蜂胶可促进哺乳羔羊的生长以及抗菌、抗氧化和免疫反应。对于 150 μL 蜂胶/kg BW/d 的剂量观察到最大的影响。01)超氧化物歧化酶的浓度。所有剂量都增加了 (P = 0.01) 非蛋白质硫醇和蛋白质硫醇的浓度,对 T250 检测到的影响最大。所有剂量均降低 (P = 0.01) 大肠杆菌计数和粪便中的总大肠菌群计数,对 T150 和 T200 观察到的影响最大。总之,数据表明在牛奶中添加蜂胶可促进哺乳羔羊的生长以及抗菌、抗氧化和免疫反应。对于 150 μL 蜂胶/kg BW/d 的剂量观察到最大的影响。对 T150 和 T200 观察到的影响最大。总之,数据表明在牛奶中添加蜂胶可促进哺乳羔羊的生长以及抗菌、抗氧化和免疫反应。对于 150 μL 蜂胶/kg BW/d 的剂量观察到最大的影响。对 T150 和 T200 观察到的影响最大。总之,数据表明在牛奶中添加蜂胶可促进哺乳羔羊的生长以及抗菌、抗氧化和免疫反应。对于 150 μL 蜂胶/kg BW/d 的剂量观察到最大的影响。
更新日期:2021-01-01
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