An inverse correlation between high-density lipoprotein cholesterol (HDL-C) and cancer risk has been shown by several epidemiological studies. Some studies have even suggested that HDL-C can be used as a prognostic marker in patients with certain types of cancer. However, whether reduced HDL-C level is a consequential or causal factor in the development and progression of cancer remains a controversial issue. In this review, we update and summarize recent advances that highlight the role of HDL and some of its components in prognosis, diagnosis and treatment of cancer.

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HDL和癌症——因果关系还需要确认吗？2020 年更新

几项流行病学研究表明，高密度脂蛋白胆固醇 (HDL-C) 与癌症风险之间存在负相关。一些研究甚至表明 HDL-C 可用作某些类型癌症患者的预后标志物。然而，HDL-C水平降低是癌症发生和进展的结果因素还是因果因素仍然是一个有争议的问题。在这篇综述中，我们更新和总结了最近的进展，这些进展突出了 HDL 及其一些成分在癌症预后、诊断和治疗中的作用。