Regular exposure to stress causes alteration in biochemical parameter but till date no specific medicine prescribed for controlling it. Current study aimed to determine the effect of Diazepam on proinflammatory and cardiac markers in stress exposed rats. Male Wistar rats were divided into four groups with six animals in each group for 90 days study. Group-1 served as a Normal Control (NC), Groups-2, as a Disease Control (DC), Group-3 as a Diazepam Control (DMC) and Group-4 as a Disease + Diazepam Treatment (DT). DMC and DT animals exposed to regular stress by forced swimming exercise method for 90 days. DMC and DT received 5 mg/kg, p.o the daily dose of Diazepam. At the end of the protocol, animals were sacrificed. The level of serum proinflammatory marker interleukin-6 in DC increased significantly (p < 0.001) while restored significantly (p < 0.001) in DT. Level of interleukin-10 in DC decreased significantly (p < 0.001) while restored significantly (p < 0.001) in DT. Level of fibrinogen was also increased by stress, which was restored significantly (p < 0.05) by diazepam. Increased level of Creatine kinase-MB (CK-MB) by stress was restored significantly (p < 0.05) by diazepam. The level of cortisol was increased also significantly (p < 0.001) and restored to normal by diazepam. The level of C-reactive protein (CRP) and cholesterol was increased significantly (p < 0.01; p < 0.001) by stress while restored significantly (p < 0.01; p < 0.001) by diazepam. Findings from results suggest that diazepam ameliorates altered proinflammatory and cardiac markers in stress exposed rats.

经常承受压力会导致生化参数发生变化，但迄今为止，还没有专门的药物来控制它。目前的研究旨在确定地西泮对应激大鼠促炎和心脏标志物的影响。雄性Wistar大鼠被分为四组，每组六只动物进行90天的研究。第 1 组作为正常对照 (NC)，第 2 组作为疾病对照 (DC)，第 3 组作为地西泮对照 (DMC)，第 4 组作为疾病 + 地西泮治疗 (DT)。DMC和DT动物通过强迫游泳运动法接受定期应激90天。DMC 和 DT 接受 5 mg/kg，每日口服地西泮剂量。在方案结束时，处死动物。DC 中血清促炎标志物白细胞介素 6 水平显着升高 (p < 0.001)，而 DT 中显着恢复 (p < 0.001)。DC 中的白细胞介素 10 水平显着下降 (p < 0.001)，而 DT 中的白细胞介素 10 水平显着恢复 (p < 0.001)。纤维蛋白原水平也因应激而增加，地西泮可显着恢复纤维蛋白原水平（p < 0.05）。地西泮可显着恢复因应激而增加的肌酸激酶-MB (CK-MB) 水平 (p < 0.05)。皮质醇水平也显着增加（p < 0.001），并通过地西泮恢复正常。应激使 C 反应蛋白 (CRP) 和胆固醇水平显着升高 (p < 0.01; p < 0.001)，而地西泮则显着恢复 (p < 0.01; p < 0.001)。结果表明，地西泮可改善应激大鼠的促炎和心脏标志物的改变。