INTRODUCTION Cerebral metabolism in obsessive-compulsive-disorder(OCD) has been the subject of numerous studies using proton magnetic resonance spectroscopy(MRS). Despite heterogeneous results, some studies have unraveled membrane turnover and energy metabolism abnormalities in different brain regions, suggesting that alterations in these processes may contribute to the pathophysiology. So far, no authors have explored phospholipids and high-energy phosphate metabolism using 31P-MRS, which allows in vivo quantification of phosphorus metabolites that are considered to be related to membrane turnover and energy metabolism. MATERIALS AND METHODS The aim of our study was to describe and compare brain metabolic changes using 31P-MRS in the striatum and the thalamus, between 23 severe OCD patients and 22 healthy controls. All subject underwent a clinical examination and a same 31P-MRS protocol. RESULTS Significantly, increased concentrations of PC, PDE,PME,GPC,PME/PCr,PDE/PCr were found in patients compared to controls in the striatum and the thalamus. PCr and tATP were decreased in the striatum. Finally, significant correlations were found in the striatum and the thalamus between illness duration and some specific measured parameters. CONCLUSION Our results showed significant modifications of the membrane and energy metabolism in the basal ganglia of severe OCD patients and suggests a link between energetic buffer and serotonin metabolism disorder.

中文翻译：

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治疗抵抗的严重强迫症患者基底节和丘脑中磷脂和高能磷酸盐代谢的改变：磷 31 核磁共振波谱研究。

引言 强迫症 (OCD) 中的脑代谢已成为使用质子磁共振波谱 (MRS) 进行的众多研究的主题。尽管结果不一，但一些研究揭示了不同大脑区域的膜更新和能量代谢异常，表明这些过程的改变可能有助于病理生理学。到目前为止，还没有作者使用 31P-MRS 探索磷脂和高能磷酸盐代谢，这允许在体内量化被认为与膜周转和能量代谢相关的磷代谢物。材料和方法 我们研究的目的是使用 31P-MRS 描述和比较 23 名严重强迫症患者和 22 名健康对照者在纹状体和丘脑中的脑代谢变化。所有受试者都接受了临床检查和相同的 31P-MRS 方案。结果 值得注意的是，与对照组相比，患者的纹状体和丘脑中 PC、PDE、PME、GPC、PME/PCr、PDE/PCr 的浓度增加。纹状体中的 PCr 和 tATP 减少。最后，在纹状体和丘脑中发现了疾病持续时间与一些特定测量参数之间的显着相关性。结论 我们的结果显示严重强迫症患者基底神经节的膜和能量代谢发生了显着改变，并表明能量缓冲与血清素代谢障碍之间存在联系。纹状体中的 PCr 和 tATP 减少。最后，在纹状体和丘脑中发现了疾病持续时间与一些特定测量参数之间的显着相关性。结论 我们的结果显示严重强迫症患者基底神经节的膜和能量代谢发生了显着改变，并表明能量缓冲与血清素代谢障碍之间存在联系。纹状体中的 PCr 和 tATP 减少。最后，在纹状体和丘脑中发现了疾病持续时间与一些特定测量参数之间的显着相关性。结论我们的结果显示严重强迫症患者基底神经节的膜和能量代谢发生显着改变，并表明能量缓冲与血清素代谢障碍之间存在联系。