Abstract The application of advanced textile materials functionalized with magnetic nanoparticles (MNP) has become increasingly important in tumor therapy. In this regard, the incorporation of MNP into polymeric filaments, so-called hybrid filaments, enables the development of magnetic heatable stents that, once implanted, are used to deliver therapeutic heat to the tumor site under the influence of an external alternating magnetic field (AMF). In this study, we investigate the hyperthermia performance of different hybrid filaments functionalized with MNP and discuss the relevant parameters influencing the heating efficiency such as MNP immobilization, agglomeration and magnetization as well as AMF settings. For this, three different MNP types (self-synthesized single domain MNP and two commercially available multi-domain MNP, BAYFERROX® and BNF-Starch) were incorporated in polypropylene filaments by melt spinning. Their heating efficiency was assessed in dependence of the AMF amplitude. Because of the blocking of Brownian rotation and bigger effective anisotropy constant caused by MNP agglomeration inside the filaments, the heating efficiency of all hybrid filaments was smaller than that of the corresponding MNP dispersed in water. Nevertheless, in all cases the heating efficiency increased with magnetic field amplitude. The highest specific loss power (SLP) values were reached for the self-synthesized particles at lower magnetic field amplitudes ( 25 kA/m). This is caused by the higher anisotropy constant of the BNF-Starch particles and their collective magnetic response at higher magnetic field amplitudes.

中文翻译：

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评估混合纺织长丝的热疗性能：不同加热剂的影响

摘要 磁性纳米粒子（MNP）功能化的先进纺织材料在肿瘤治疗中的应用变得越来越重要。在这方面，将 MNP 掺入聚合物长丝，即所谓的混合长丝，可以开发磁性可加热支架，一旦植入，就可以在外部交变磁场的影响下向肿瘤部位提供治疗热量。 AMF）。在这项研究中，我们研究了用 MNP 功能化的不同混合长丝的热疗性能，并讨论了影响加热效率的相关参数，如 MNP 固定、团聚和磁化以及 AMF 设置。为此，三种不同的 MNP 类型（自合成的单域 MNP 和两种市售的多域 MNP，BAYFERROX® 和 BNF-Starch) 通过熔体纺丝被掺入聚丙烯长丝中。它们的加热效率根据 AMF 幅度进行评估。由于MNP在长丝内部团聚导致布朗旋转受阻和更大的有效各向异性常数，所有杂化长丝的加热效率都小于分散在水中的相应MNP的加热效率。尽管如此，在所有情况下，加热效率都随着磁场幅度的增加而增加。在较低的磁场幅度 (25 kA/m) 下，自合成粒子达到了最高的比损耗功率 (SLP) 值。这是由 BNF-淀粉粒子较高的各向异性常数及其在较高磁场幅度下的集体磁响应引起的。