We describe a fatal kidney disease in green iguanas (Iguana iguana), associated with severe nephromegaly. Affected animals have enlarged kidneys, which fill the pelvic cavity, leading to compression of adjacent organs, obstipation and, ultimately, death. The pathological features of this disease have been poorly described and its aetiology is unknown. We performed detailed gross and histological analyses of 17 green iguanas with a clinical diagnosis of nephromegaly, and compared the results with those of eight healthy controls. Grossly, the kidneys of all 17 individuals were markedly enlarged and the distal colons were distended and overfilled with faecal contents. Histopathological examination revealed that these enlarged kidneys consisted mainly of tubular hyperplasia, resembling poorly developed proximal segments. The nephrogenic zones were either poorly developed or absent. There was a reduction in the density of glomeruli and the distal segments were reduced in number. There was no histological evidence of an aetiology for the nephron disruption and nephromegaly.

我们描述了绿鬣蜥（Iguana iguana)，与严重的肾肿大有关。受影响的动物肾脏增大，填满盆腔，导致邻近器官受压、便秘，最终导致死亡。这种疾病的病理特征描述不充分，病因不明。我们对 17 只临床诊断为肾肿大的绿鬣蜥进行了详细的大体和组织学分析，并将结果与​​ 8 只健康对照的结果进行了比较。大体上，所有 17 个人的肾脏都显着增大，远端结肠扩张并被粪便内容物填满。组织病理学检查显示，这些增大的肾脏主要由肾小管增生组成，类似于发育不良的近端节段。肾源区要么发育不良，要么不存在。肾小球密度降低，远端节段数量减少。没有肾单位破坏和肾肿大病因的组织学证据。