Polysaccharide storage myopathies have been described in several animal species and are characterized by periodic acid–Schiff (PAS)-positive, diastase-resistant intrasarcoplasmic inclusions in myocytes. Skeletal and cardiac muscle samples from a subset of a single pod of stranded long-finned pilot whales (Globicephala melas) were evaluated by light and transmission electron microscopy. Twelve individuals demonstrated sporadic basophilic packets of PAS-positive, diastase-resistant complex polysaccharide material, either centrally or peripherally, in skeletal and cardiac myocytes. Few microscopic myopathic changes were found but included focal inflammation and internalized nuclei. Ultrastructurally, the inclusions consisted of loosely arranged, tangled filaments and were not membrane-bound, which is consistent with polyglucosan inclusions. Within skeletal muscle, the number of inclusions had a marginal statistically significant (P = 0.0536) correlation with length, as a proxy for age, suggesting that such inclusions in skeletal muscles may be age-related, although the cause remains unclear.

多糖贮积性肌病已在几种动物物种中得到描述，其特征在于肌细胞中高碘酸-希夫 (PAS) 阳性、抗淀粉酶的肌浆内包涵体。来自单个搁浅长鳍领航鲸（Globicephala melas）的一个子集的骨骼肌和心肌样本) 通过光学和透射电子显微镜进行评估。12 名个体在骨骼和心肌细胞中的中枢或外周表现出散发性 PAS 阳性、抗淀粉酶复合多糖物质的嗜碱性包。很少发现微观肌病变化，但包括局灶性炎症和内化细胞核。在超微结构上，包裹体由排列松散、缠结的细丝组成，没有膜结合，这与多聚葡聚糖包裹体一致。在骨骼肌中，内含物的数量 与长度具有边际显着性（P = 0.0536）相关性，作为年龄的代表，表明骨骼肌中的内含物可能与年龄有关，尽管原因尚不清楚。