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A Standardized and Comprehensive Approach to the Management of Cardiogenic Shock
JACC: Heart Failure ( IF 10.3 ) Pub Date : 2020-10-26 , DOI: 10.1016/j.jchf.2020.09.005
Behnam N Tehrani 1 , Alexander G Truesdell 2 , Mitchell A Psotka 1 , Carolyn Rosner 1 , Ramesh Singh 1 , Shashank S Sinha 1 , Abdulla A Damluji 1 , Wayne B Batchelor 1
Affiliation  

Cardiogenic shock is a hemodynamically complex syndrome characterized by a low cardiac output that often culminates in multiorgan system failure and death. Despite recent advances, clinical outcomes remain poor, with mortality rates exceeding 40%. In the absence of adequately powered randomized controlled trials to guide therapy, best practices for shock management remain nonuniform. Emerging data from North American registries, however, support the use of standardized protocols focused on rapid diagnosis, early intervention, ongoing hemodynamic assessment, and multidisciplinary longitudinal care. In this review, the authors examine the pathophysiology and phenotypes of cardiogenic shock, benefits and limitations of current therapies, and they propose a standardized and team-based treatment algorithm. Lastly, they discuss future research opportunities to address current gaps in clinical knowledge.



中文翻译:


心源性休克管理的标准化综合方法



心源性休克是一种复杂的血流动力学综合征,其特征是心输出量低,常常导致多器官系统衰竭和死亡。尽管最近取得了进展,但临床结果仍然很差,死亡率超过 40%。由于缺乏足够有力的随机对照试验来指导治疗,休克管理的最佳实践仍然不一致。然而,来自北美登记处的新数据支持使用专注于快速诊断、早期干预、持续血流动力学评估和多学科纵向护理的标准化方案。在这篇综述中,作者研究了心源性休克的病理生理学和表型、当前疗法的益处和局限性,并提出了一种标准化和基于团队的治疗算法。最后,他们讨论了解决当前临床知识差距的未来研究机会。

更新日期:2020-10-30
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