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Effects of inhaled combined Benzene, Toluene, Ethylbenzene, and Xylenes (BTEX): Toward an environmental exposure model
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-10-24 , DOI: 10.1016/j.etap.2020.103518
Cameron J. Davidson , John H. Hannigan , Scott E. Bowen

Combined environmental exposures to the volatile organic compounds (VOCs) Benzene, Toluene, Ethylbenzene, and Xylene (BTEX) pose clear risks to public health. Research into these risks is under-studied even as BTEX levels in the atmosphere are predicted to rise. This review focuses on the available literature using single- and combined-BTEX component inhaled solvent exposures in animal models, necessarily also drawing on findings from models of inhalant abuse and occupational exposures. Health effects of these exposures are discussed for multiple organ systems, but with particular attention on neurobehavioral outcomes such as locomotor activity, impulsivity, learning, and psychopharmacological responses. It is clear that animal models have significant differences in the concentrations, durations and patterns of exposure. Experimental evidence of the deleterious health and neurobehavioral consequences of exposures to the individual components of BTEX were found, but these effects were typically assessed using concentrations and exposure patterns not characteristic of environmental exposure. Future studies with animal models designed appropriately to explore combined BTEX will be necessary and advantageous to discovering health outcomes and more subtle neurobehavioral impacts of long-term environmental exposures.



中文翻译:

吸入的混合苯,甲苯,乙苯和二甲苯(BTEX)的影响:建立环境暴露模型

苯,甲苯,乙苯和二甲苯(BTEX)对挥发性有机化合物(VOC)的综合环境暴露对公共健康构成明显的风险。即使预计大气中的BTEX含量会上升,对这些风险的研究也未得到充分研究。这篇综述着重于在动物模型中使用单一和组合BTEX成分吸入溶剂暴露的现有文献,还必须借鉴吸入滥用和职业暴露模型的发现。讨论了这些暴露对多种器官系统的健康影响,但特别注意了神经行为结果,例如运动活动,冲动,学习和心理药理反应。显然,动物模型在浓度,持续时间和暴露方式上有显着差异。发现了暴露于BTEX各个成分的有害健康和神经行为后果的实验证据,但通常使用环境暴露所没有的浓度和暴露模式评估这些影响。未来使用适当设计以探索组合BTEX的动物模型进行的研究对于发现健康结果以及长期环境暴露的更微妙的神经行为影响将是必要且有利的。

更新日期:2020-10-30
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