Cyclic water vole population explosions can be controlled in some European countries with anticoagulant rodenticides leading sometimes to wildlife poisonings due to the toxin’s tissue persistence. Here, we analyzed the pharmacokinetics of rodenticide residues in voles and we explored potential ways of improving the mass application of these agents based on the concept of stereoisomers.

We demonstrated the dramatic persistence of bromadiolone in vole tissues with a hepatic half-life of about 10–30 days, while the tissue persistence of chlorophacinone is rather short with a hepatic half-life of about one day. The dramatic persistence of bromadiolone is due to the trans-isomer group (the major compound in bromadiolone), while the cis-isomer group has a short half-life. Because of resistance to chlorophacinone, the cis-bromadiolone isomers may constitute an excellent compromise between efficacy and ecotoxicological risk to control voles. A mathematical model is proposed to favor the development of baits mixed with cis-isomer groups.

在某些欧洲国家，使用抗凝灭鼠剂可以控制周期性水田鼠的爆炸，由于毒素的组织持久性，有时导致野生生物中毒。在这里，我们分析了田鼠中杀鼠剂残留的药代动力学，并根据立体异构体的概念探索了改善这些药剂大规模应用的潜在途径。

我们证明了丙二酮在田鼠组织中的持久性非常强，肝半衰期约为10–30天，而氯霉素的组织持久性很短，肝半衰期约为1天。溴丙二醇酮的显着持久性归因于反式异构体基团（溴丙二醇酮中的主要化合物），而顺式异构体基团的半衰期短。由于对氯霉素具有抗性，因此顺式-溴苯丙隆酮异构体可能在控制田鼠的功效和生态毒理风险之间构成一个极好的折衷方案。提出了一个数学模型来促进与顺式异构体混合的诱饵的发展。