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The innovative potential of selenium-containing agents for fighting cancer and viral infections
Drug Discovery Today ( IF 6.5 ) Pub Date : 2020-10-23 , DOI: 10.1016/j.drudis.2020.10.014
Wesam Ali 1 , Rosaria Benedetti 2 , Jadwiga Handzlik 3 , Clemens Zwergel 4 , Cecilia Battistelli 5
Affiliation  

Selenium-containing compounds have emerged as a potentially promising treatment for viral infections and tumor development and dissemination. Selenium per se is often considered as a toxic element with little or no beneficial effects, but considerable advances have been made in the understanding of the complex biology, chemistry and drug delivery of this element, especially when it is included in bioactive molecules. Here, we summarize and critically discuss recent findings in the field of selenium-based applications for the treatment of cancer and viral infections.



中文翻译:

含硒药物对抗癌症和病毒感染的创新潜力

含硒化合物已成为治疗病毒感染和肿瘤发展和传播的潜在有希望的治疗方法。硒本身通常被认为是一种有毒元素,几乎没有或没有有益作用,但在理解这种元素的复杂生物学、化学和药物递送方面取得了相当大的进展,尤其是当它包含在生物活性分子中时。在这里,我们总结并批判性地讨论了基于硒的应用领域的最新发现,用于治疗癌症和病毒感染。

更新日期:2020-10-23
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