The generation of adult hematopoietic stem and progenitor cells (HSPCs) from embryonic and induced pluripotent stem cells (iPSCs) will provide therapeutic benefits but is currently elusive. In this issue of Developmental Cell, Frame et al. reveal that the inflammasome has a key role in HSPCs specification during endothelial-to-hematopoietic transition (EHT).

中文翻译：

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糖仓促：通过炎症小体为血细胞增压

从胚胎和诱导多能干细胞（iPSC）生成成人造血干细胞和祖细胞（HSPC）将提供治疗益处，但目前仍难以捉摸。在本期《发育细胞》中，Frame等人。揭示了炎性小体在内皮细胞向造血细胞过渡（EHT）的过程中在HSPC规范中具有关键作用。