The purpose of this study was to compare the effects of exercise in cold-dry (CC, -20 °C, RH 40%) and normal conditions (NC, 20 °C, RH 60%) on salivary levels of pro-inflammatory and regulatory cytokines (IL-1RA, IL-8, and IL-5) and the airway response (FEV1 and FVC) in young healthy males. Participants (n = 11, age: 23.6 ± 3.1 years) completed an incremental to maximal exercise test and two exercise sessions in an environmental chamber in random order. Saliva samples were collected, and spirometry was performed prior to the maximal exercise test as well as pre and post-exercise for the CC and NC sessions. IL-8 levels increased from pre to post-exercise during NC but not during CC; the opposite trend was observed for IL-1RA. These data may provide insight into pathways associated with the development of airway hyperresponsiveness in healthy athletes.

中文翻译：

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在寒冷干燥和正常条件下运动引起的唾液 IL-8 和 IL-1RA 变化

本研究的目的是比较在冷干（CC，-20 °C，RH 40%）和正常条件（NC，20 °C，RH 60%）下运动对促炎和促炎的唾液水平的影响。调节细胞因子（IL-1RA、IL-8 和 IL-5）和年轻健康男性的气道反应（FEV1 和 FVC）。参与者（n = 11，年龄：23​​.6 ± 3.1 岁）在环境室中以随机顺序完成了最大运动测试和两次运动课程。收集唾液样本，并在最大运动测试之前以及 CC 和 NC 会话的运动前和运动后进行肺活量测定。在 NC 期间，IL-8 水平从运动前到运动后增加，但在 CC 期间没有；对于 IL-1RA，观察到相反的趋势。