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Does sleep-dependent consolidation favour weak memories?
Cortex ( IF 3.6 ) Pub Date : 2020-10-28 , DOI: 10.1016/j.cortex.2020.10.005
Marit Petzka 1 , Ian Charest 1 , George M Balanos 2 , Bernhard P Staresina 1
Affiliation  

Sleep stabilizes newly acquired memories, a process referred to as memory consolidation. According to recent studies, sleep-dependent consolidation processes might be deployed to different extents for different types of memories. In particular, weaker memories might benefit greater from post-learning sleep than stronger memories. However, under standard testing conditions, sleep-dependent consolidation effects for stronger memories might be obscured by ceiling effects. To test this possibility, we devised a new memory paradigm (Memory Arena) in which participants learned temporospatial arrangements of objects. Prior to a delay period spent either awake or asleep, training thresholds were controlled to yield relatively weak or relatively strong memories. After the delay period, retrieval difficulty was controlled via the presence or absence of a retroactive interference task. Under standard testing conditions (no interference), a sleep-dependent consolidation effect was indeed observed for weaker memories only. Critically though, with increased retrieval demands, sleep-dependent consolidation effects were seen for both weaker and stronger memories. These results suggest that all memories are consolidated during sleep, but that memories of different strengths require different testing conditions to unveil their benefit from post-learning sleep.



中文翻译:

依赖睡眠的巩固是否有利于弱记忆?

睡眠可以稳定新获得的记忆,这一过程称为记忆巩固。根据最近的研究,对于不同类型的记忆,可能会在不同程度上部署依赖于睡眠的巩固过程。特别是,较弱的记忆可能比较强的记忆更能从学习后睡眠中受益。然而,在标准测试条件下,睡眠依赖性巩固记忆的效果可能会被天花板效应所掩盖。为了测试这种可能性,我们设计了一种新的记忆范式(记忆竞技场),参与者可以在其中学习对象的时空排列。在清醒或睡眠的延迟期之前,控制训练阈值以产生相对较弱或相对较强的记忆。延迟期过后,检索难度通过是否存在追溯干扰任务来控制。在标准测试条件(无干扰)下,确实仅在较弱的记忆中观察到了睡眠依赖性巩固效应。但重要的是,随着检索需求的增加,对于较弱和较强的记忆都存在依赖于睡眠的巩固效应。这些结果表明,所有记忆在睡眠期间都会得到巩固,但不同强度的记忆需要不同的测试条件才能揭示其从学习后睡眠中获得的益处。

更新日期:2020-12-01
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