当前位置: X-MOL 学术Cortex › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Parallel fast and slow motor inhibition processes in Joint Action coordination
Cortex ( IF 3.6 ) Pub Date : 2020-10-21 , DOI: 10.1016/j.cortex.2020.09.029
Pasquale Cardellicchio 1 , Elisa Dolfini 1 , Luciano Fadiga 2 , Alessandro D'Ausilio 2
Affiliation  

Motor inhibition is essential to adapt to an ever-changing environment and to noise in state prediction. As a consequence, inhibitory motor control must also play a key role during Joint Action (JA) tasks, where the motor system has to further integrate inferences about others' action. Yet, very little research has been carried out on the contribution of motor inhibition in JA tasks. Here, we used an interactive task in which subjects were required to open a bottle with one hand. The bottle was held and stabilized by a co-actor (JA) or by a mechanical holder (vice clamp, no-JA). A first motion capture study characterized the reaching and grasping kinematics of the two conditions. In a second study, by means of Transcranial Magnetic Stimulation (TMS), we measured (i) corticospinal excitability (CSE), (ii) cortical silent period (cSP) and (iii) short-interval intracortical inhibition (sICI), during the reaching phase of the task. These latter two indexes respectively reflect slow corticospinal (GABAb-mediated) and fast intracortical (GABAa-mediated) inhibition. We found no modulation for CSE, while cSP was increased and intracortical inhibition was downregulated during JA. Interestingly, the cSP correlated with partners' predictability as a whole and with partners’ behaviour in the previous trial. These results, beside showing clear dissociation between fast and slow inhibition during JA, also shed new light on the predictive role played by corticospinal inhibitory mechanisms in online mutual behavioural co-adaptation.



中文翻译:

联合动作协调中并行的快速和慢速运动抑制过程

电机抑制对于适应不断变化的环境和状态预测中的噪声至关重要。因此,抑制性运动控制也必须在“联合行动”(JA)任务中发挥关键作用,在该任务中,运动系统必须进一步整合有关他人行为的推论。然而,关于运动抑制在JA任务中的作用的研究很少。在这里,我们使用了一个交互式任务,要求受试者用一只手打开一个瓶子。通过共同作用器(JA)或机械支架(副夹,no-JA)固定并稳定瓶子。第一次运动捕捉研究的特征是这两种情况的达到和掌握运动学。在第二项研究中,我们通过经颅磁刺激(TMS)测量了(i)皮质脊髓兴奋性(CSE),(ii)在任务到达阶段,静默期(cSP)和(iii)短间隔皮质内抑制(sICI)。后两个指标分别反映了缓慢的皮质脊髓(GABA A介导的)和快速的皮质内(GABA A介导的)抑制。我们发现在JA期间cSE没有调节,而cSP升高且皮层内抑制被下调。有趣的是,在先前的试验中,cSP与合作伙伴的整体可预测性以及合作伙伴的行为相关。这些结果,除了显示出JA期间快速抑制和缓慢抑制之间的明显分离外,还为皮质脊髓抑制机制在在线相互行为共适应中的预测作用提供了新的启示。后两个指标分别反映了缓慢的皮质脊髓(GABA A介导的)和快速的皮质内(GABA A介导的)抑制。我们发现,在JA期间,cSE没有调节,而cSP升高且皮层内抑制被下调。有趣的是,在先前的试验中,cSP与合作伙伴的整体可预测性以及合作伙伴的行为相关。这些结果,除了显示出JA期间快速抑制和缓慢抑制之间的明显分离外,还为皮质脊髓抑制机制在在线相互行为共适应中的预测作用提供了新的启示。后两个指标分别反映了缓慢的皮质脊髓(GABA A介导的)和快速的皮质内(GABA A介导的)抑制。我们发现,在JA期间,cSE没有调节,而cSP升高且皮层内抑制被下调。有趣的是,在先前的试验中,cSP与合作伙伴的整体可预测性以及合作伙伴的行为相关。这些结果,除了显示出JA期间快速抑制和缓慢抑制之间的明显分离外,还为皮质脊髓抑制机制在在线相互行为共适应中的预测作用提供了新的启示。cSP与合作伙伴的整体可预测性以及先前试验中合作伙伴的行为相关。这些结果,除了显示出JA期间快速抑制和缓慢抑制之间的明显分离外,还为皮质脊髓抑制机制在在线相互行为共适应中的预测作用提供了新的启示。cSP与合作伙伴的整体可预测性以及先前试验中合作伙伴的行为相关。这些结果,除了显示出JA期间快速抑制和缓慢抑制之间的明显分离外,还为皮质脊髓抑制机制在在线相互行为共适应中的预测作用提供了新的启示。

更新日期:2020-11-12
down
wechat
bug