Baicalin, a main bioactive compound of Scutellaria baicalensis, has a variety of pharmacological activities including antioxidation, anti-inflammation and hepatoprotection. However, there are few reports on these biological activities in fish. Therefore, the aim of this study was to assess the effects of baicalin on growth performance, antioxidative status and hepatoprotection in tilapia. The fish were fed on different doses of baicalin (0, 0.4, 0.8 and 1.6 g/kg diet). After feeding 60 days, parts of fishes were netted, and the blood, liver, gills and muscle tissues were collected to analyze the antioxidative effect. The remaining fishes were injected with saline or hydrogen peroxide (H₂O₂) for challenge test. The results showed that the specific growth rate of fish was slightly increased in three baicalin treatments, and the feed efficiency was clearly improved in 0.4 g/kg baicalin treatment. Meanwhile, the antioxidative capacity in blood, liver and/or gill was enhanced in treatments with 0.4, 0.8 and/or 1.6 g/kg baicalin. After challenge test, the pre-treatments with baicalin effectively alleviated H₂O₂-induced liver injury. In serum and liver, pre-treatments with 0.8 and/or 1.6 g/kg baicalin suppressed the oxidative damage induced by H₂O₂, as evidenced by improvement of the levels of SOD, T-AOC and GSH and the decline of MDA level. More important, pre-treatments with 0.4, 0.8 and/or 1.6 g/kg baicalin blocked the upregulation of mRNA levels of tlr1, myd88, irak4, rela, tnf-α and il-1β in H₂O₂-induced liver injury. In summary, dietary baicalin supplementation could improve feed efficiency, enhance antioxidative ability and alleviate oxidative stress-induced hepatotoxicity in tilapia.

黄ical素是黄cut的主要生物活性化合物，具有多种药理活性，包括抗氧化，抗炎和保肝作用。但是，关于鱼类中这些生物活性的报道很少。因此，本研究的目的是评估黄ical苷对罗非鱼的生长性能，抗氧化状态和保肝作用。给鱼喂不同剂量的黄fed素（0、0.4、0.8和1.6 g / kg饮食）。喂食60天后，将部分鱼捕网，收集血液，肝脏，腮和肌肉组织以分析其抗氧化作用。其余的鱼注射盐水或过氧化氢（H ₂ O ₂）进行挑战测试。结果表明，在三种黄in苷处理中，鱼的比生长速率略有提高，在0.4 g / kg黄ical苷处理中，饲料效率明显提高。同时，用0.4、0.8和/或1.6 g / kg黄ba苷治疗可增强血液，肝脏和/或or的抗氧化能力。激发试验后，用黄ical苷进行的预处理可有效减轻H ₂ O ₂引起的肝损伤。在血清和肝脏中，用0.8和/或1.6 g / kg黄ical苷进行预处理可抑制H ₂ O ₂引起的氧化损伤，如SOD，T-AOC和GSH含量的改善以及MDA含量的下降所证明。更重要的是，预先治疗与0.4，0.8和/或1.6克/千克黄芩苷阻断的mRNA水平的上调TLR1，MyD88的，IRAK4，RELA，TNF-α和IL-1β H中₂ ö ₂诱导的肝损伤。总之，日粮黄diet素可以提高饲料效率，增强抗氧化能力并减轻罗非鱼的氧化应激引起的肝毒性。