Curcumin (C) is a natural antioxidant which has many beneficial effects. However, poor bioavailability and less water solubility render it unsuitable as an anti-cancer drug. Herein, curcumin was delivered through Mesoporous silica nanoparticle (MSN) based drug delivery system to enhance its anticancer efficacy. Targeted delivery of curcumin in cancer cells was also achieved by conjugating hyaluronic acid (HA) on the surface of MSN. HA showed its targeting ability through the binding with CD-44 receptors in cancer cells. The synthesis of MSN-HA-C was verified by used several characterization techniques like TEM, SEM, XRD and DLS. MSN-HA-C showed diameter of ∼ 75 nm with negatively charged surface and drug loading content of 14.76 %. The synthesized nanohybrid showed MDA-MB-231 cell death by the induction of ROS, cell cycle arrest and modulation of NF-κB and Bax mediated apoptotic pathway. The nanohybrid also effectually decreased tumor volume in tumor-bearing mice compared with free C due to the increased bioavailability and higher cellular uptake of C in tumor tissue. Overall, the study offered that MSN-HA-C has increased anticancer efficacy than that of free curcumin.

姜黄素（C）是一种天然抗氧化剂，具有许多有益作用。然而，不良的生物利用度和较低的水溶性使其不适合用作抗癌药。本文中，姜黄素通过基于介孔二氧化硅纳米颗粒（MSN）的药物递送系统递送，以增强其抗癌功效。姜黄素在癌细胞中的靶向递送还通过结合MSN表面的透明质酸（HA）实现。HA通过与癌细胞中的CD-44受体结合而显示出靶向作用。MSN-HA-C的合成已通过多种表征技术（如TEM，SEM，XRD和DLS）进行了验证。MSN-HA-C的直径约为75 nm，表面带负电，载药量为14.76％。合成的纳米杂交体通过诱导ROS显示MDA-MB-231细胞死亡，细胞周期阻滞和调节NF-κB和Bax介导的凋亡途径。与游离C相比，由于在肿瘤组织中C的生物利用度提高和细胞对C的吸收更高，因此纳米杂交还有效地降低了荷瘤小鼠的肿瘤体积。总体而言，该研究提供了MSN-HA-C比游离姜黄素具有更高的抗癌功效。