To evaluate the global prevalence of antenatal depression and clarify its potential associated factors, we conducted two systematic reviews and meta-analyses, where appropriate. PubMed, Web of Science, and Embase were used to identify studies published up to Feb 28, 2019. The pooled prevalence of any antenatal depression across 173 studies with 182 reports was 20.7% (95% CI 19.4–21.9%, P = 0.000, I² = 98.4%), and the pooled prevalence of major antenatal depression across 72 studies with 79 reports was 15.0% (95% CI 13.6–16.3%, P = 0.000, I² = 97.8%). The prevalence of antenatal depression was higher in low- or lower-middle-income countries, and in studies using self-report instruments or conducted after the year 2010. History of depression, lack of social support, single/separated/divorced status, unplanned pregnancy, unemployment, experience of violence, and smoking before or during pregnancy were significantly associated with antenatal depression. The results of our study indicated that a significant number of pregnant women experience depression and verified some factors that are related to this disorder. As countermeasures, it is important to develop effective risk assessment strategies as well as prevention and intervention strategies for antenatal depression based on its associated factors.

为了评估产前抑郁症的全球患病率并阐明其潜在的相关因素，我们在适当的情况下进行了两项系统评价和荟萃分析。PubMed、Web of Science 和 Embase 用于确定截至 2019 年 2 月 28 日发表的研究。在 173 项研究和 182 份报告中，任何产前抑郁症的汇总患病率为 20.7%（95% CI 19.4-21.9%，P  = 0.000，I ²  = 98.4%），72 项研究和 79 份报告的合并严重产前抑郁症患病率为 15.0%（95% CI 13.6-16.3%，P  = 0.000，I ² = 97.8%）。在低收入或中低收入国家以及使用自我报告工具或 2010 年后进行的研究中，产前抑郁症的患病率较高。抑郁症史、缺乏社会支持、单身/分居/离婚状态、计划外怀孕、失业、暴力经历和怀孕前或怀孕期间吸烟与产前抑郁症显着相关。我们的研究结果表明，相当多的孕妇患有抑郁症，并证实了与这种疾病有关的一些因素。作为对策，重要的是根据产前抑郁症的相关因素制定有效的风险评估策略以及预防和干预策略。