OBJECTIVE To determine the optimal methods for measuring mismatch negativity (MMN), an auditory event-related potential (ERP), and quantify sources of MMN variance in a multisite setting. METHODS Reliability of frequency, duration, and double (frequency + duration) MMN was determined from eight traveling subjects, tested on two occasions at eight laboratory sites. Deviant-specific variance components were estimated for MMN peak amplitude and latency measures using different ERP processing methods. Generalizability (G) coefficients were calculated using two-facet (site and occasion), fully-crossed models and single-facet (occasion) models within each laboratory to assess MMN reliability. RESULTS G-coefficients calculated from two-facet models indicated fair (0.4 < G<=0.6) duration MMN reliability at electrode Fz, but poor (G < 0.4) double and frequency MMN reliability. Single-facet G-coefficients averaged across laboratory resulted in improved reliability (G > 0.5). MMN amplitude reliability was greater than latency reliability, and reliability with mastoid referencing significantly outperformed nose-referencing. CONCLUSIONS EEG preprocessing methods have an impact on the reliability of MMN amplitude. Within site MMN reliability can be excellent, consistent with prior single site studies. SIGNIFICANCE With standardized data collection and ERP processing, MMN can be reliably obtained in multisite studies, providing larger samples sizeswithin rare patient groups.

中文翻译：

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多地点、旅行受试者研究中错配负性事件相关电位的可靠性

目的 确定测量失配负性 (MMN)、听觉事件相关电位 (ERP) 的最佳方法，并量化多站点环境中 MMN 方差的来源。方法 频率、持续时间和双倍（频率 + 持续时间）MMN 的可靠性由八个旅行对象确定，在八个实验室地点进行了两次测试。使用不同的 ERP 处理方法估计 MMN 峰值幅度和延迟测量的偏差特定方差分量。使用两个方面（地点和场合）、完全交叉模型和每个实验室内的单方面（场合）模型计算通用性 (G) 系数，以评估 MMN 的可靠性。结果 从两面模型计算的 G 系数表明电极 Fz 的持续时间 MMN 可靠性一般 (0.4 < G<=0.6)，但较差 (G < 0. 4）双频MMN可靠性。跨实验室平均的单面 G 系数提高了可靠性（G > 0.5）。MMN 振幅可靠性大于延迟可靠性，乳突参考的可靠性显着优于鼻参考。结论 EEG 预处理方法对MMN 幅度的可靠性有影响。站点内 MMN 可靠性非常好，与之前的单站点研究一致。意义 通过标准化的数据收集和 ERP 处理，可以在多中心研究中可靠地获得 MMN，从而在罕见的患者群体中提供更大的样本量。乳突参考的可靠性和可靠性显着优于鼻子参考。结论 EEG 预处理方法对MMN 幅度的可靠性有影响。站点内 MMN 可靠性非常好，与之前的单站点研究一致。意义 通过标准化的数据收集和 ERP 处理，可以在多中心研究中可靠地获得 MMN，从而在罕见的患者群体中提供更大的样本量。乳突参考的可靠性和可靠性显着优于鼻子参考。结论 EEG 预处理方法对MMN 幅度的可靠性有影响。站点内 MMN 可靠性非常好，与之前的单站点研究一致。意义 通过标准化的数据收集和 ERP 处理，可以在多中心研究中可靠地获得 MMN，从而在罕见的患者群体中提供更大的样本量。