Oxidative cyanation of sp³C–H bonds at the α position of amines was achieved using CoCuFe₂O₄ as a catalyst and NaCN as an inexpensive cyanide source at room temperature.

CoCuFe₂O₄ was found to be an active catalyst for Csp [3]-Csp coupling, efficiently delivering valuable α-aminonitriles from tertiary/secondary amines in good yields. The corresponding products were obtained with high selectivity toward α position. In addition, functional group tolerance offered the opportunity for application in late-stage functionalization of biologically active molecules. This transformation proceeds convenient on a gram-scale, and the catalyst can be reused for several runs with consistent catalytic activity.

在室温下，使用CoCuFe ₂ O ₄作为催化剂，使用NaCN作为廉价的氰化物源，可实现胺α位处sp ³ C–H键的氧化氰化。

发现CoCuFe ₂ O ₄是Csp [3] -Csp偶联的活性催化剂，可有效地以高收率从叔胺/仲胺传递有价值的α-氨基腈。获得了对α位置具有高选择性的相应产物。此外，官能团耐受性为生物活性分子的后期功能化应用提供了机会。这种转化以克为单位方便地进行，并且该催化剂可以在具有恒定催化活性的情况下重复使用几次。