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Roles of protein arginine methyltransferase 1 (PRMT1) in brain development and disease
Biochimica et Biophysica Acta (BBA) - General Subjects ( IF 3 ) Pub Date : 2020-10-28 , DOI: 10.1016/j.bbagen.2020.129776
Misuzu Hashimoto , Akiyoshi Fukamizu , Tsutomu Nakagawa , Yasuhiko Kizuka

Background

Protein arginine methyltransferase 1 (PRMT1), a major type I arginine methyltransferase in mammals, methylates histone and non-histone proteins to regulate various cellular functions such as transcription, DNA damage response, and signal transduction.

Scope of review

This review summarizes previous and recent studies on PRMT1 functions in major cell types of the central nervous system. We also discuss the potential involvement of PRMT1 in neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal dementia. Also, we raise key questions that must be addressed in the future to more precisely understand the roles of PRMT1.

Major conclusions

Recent studies revealed that PRMT1 is essential for the development of neurons, astrocytes, and oligodendrocytes, although further investigation using cell type-specific PRMT1-deficient animals is required. In addition, the relevance of PRMT1 in neurodegenerative diseases will continue to be a hot topic.

General significance

PRMT1 is important for neural development and neurodegenerative diseases.



中文翻译:

蛋白质精氨酸甲基转移酶1(PRMT1)在大脑发育和疾病中的作用

背景

蛋白质精氨酸甲基转移酶1(PRMT1)是哺乳动物中的主要I型精氨酸甲基转移酶,可对组蛋白和非组蛋白进行甲基化,以调节各种细胞功能,例如转录,DNA损伤反应和信号转导。

审查范围

这篇综述总结了有关PRMT1在中枢神经系统主要细胞类型中的功能的先前和最近的研究。我们还讨论了PRMT1在神经退行性疾病(如肌萎缩性侧索硬化和额颞痴呆)中的潜在参与。此外,我们提出了将来必须解决的关键问题,以更准确地了解PRMT1的作用。

主要结论

最近的研究表明,PRMT1对于神经元,星形胶质细胞和少突胶质细胞的发育至关重要,尽管需要使用细胞类型特异性PRMT1缺陷动物进行进一步的研究。此外,PRMT1在神经退行性疾病中的相关性将继续成为热门话题。

一般意义

PRMT1对于神经发育和神经退行性疾病很重要。

更新日期:2020-11-02
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