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3,3′-Diselenodipropionic acid (DSePA): A redox active multifunctional molecule of biological relevance
Biochimica et Biophysica Acta (BBA) - General Subjects ( IF 3 ) Pub Date : 2020-10-24 , DOI: 10.1016/j.bbagen.2020.129768
A. Kunwar , K. Indira Priyadarsini , Vimal K. Jain

Background

Extensive research is being carried out globally to design and develop new selenium compounds for various biological applications such as antioxidants, radio-protectors, anti-carcinogenic agents, biocides, etc. In this pursuit, 3,3′-diselenodipropionic acid (DSePA), a synthetic organoselenium compound, has received considerable attention for its biological activities.

Scope of review

This review intends to give a comprehensive account of research on DSePA so as to facilitate further research activities on this organoselenium compound and to realize its full potential in different areas of biological and pharmacological sciences.

Major conclusions

It is an interesting diselenide structurally related to selenocystine. It shows moderate glutathione peroxidase (GPx)-like activity and is an excellent scavenger of reactive oxygen species (ROS). Exposure to radiation, as envisaged during radiation therapy, has been associated with normal tissue side effects and also with the decrease in selenium levels in the body. In vitro and in vivo evaluation of DSePA has confirmed its ability to reduce radiation induced side effects into normal tissues. Administration of DSePA through intraperitoneal (IP) or oral route to mice in a dose range of 2 to 2.5 mg/kg body weight has shown survival advantage against whole body irradiation and a significant protection to lung tissue against thoracic irradiation. Pharmacokinetic profiling of DSePA suggests its maximum absorption in the lung.

General significance

Research work on DSePA reported in fifteen years or so indicates that it is a promising multifunctional organoselenium compound exhibiting many important activities of biological relevance apart from radioprotection.



中文翻译:

3,3'-二硒二丙酸(DSePA):具有生物相关性的氧化还原活性多功能分子

背景

全球范围内正在进行广泛的研究,以设计和开发用于各种生物应用的新型硒化合物,例如抗氧化剂,放射防护剂,抗癌剂,杀生物剂等。在此追求中,3,3'-二硒二丙酸(DSePA),合成的有机硒化合物因其生物活性而受到了广泛的关注。

审查范围

这篇综述旨在全面介绍DSePA的研究,以促进对该有机硒化合物的进一步研究活动,并实现其在生物和药理科学不同领域的全部潜力。

主要结论

这是一种与硒代半胱氨酸结构相关的有趣的二硒化物。它显示出中等的谷胱甘肽过氧化物酶(GPx)样活性,并且是活性氧(ROS)的优良清除剂。如放射治疗期间所设想的,暴露于放射线已与正常组织的副作用以及体内硒水平的降低有关。体外体内DSePA的评估已证实其具有减少辐射诱发的正常组织副作用的能力。通过腹膜内(IP)或口服途径以2至2.5 mg / kg体重的剂量向小鼠施用DSePA已显示出对全身辐射的生存优势,并对肺组织对胸腔辐射的显着保护。DSePA的药代动力学分析表明其在肺中的吸收最大。

一般意义

在十五年左右的时间里,有关DSePA的研究工作表明,它是一种很有前途的多功能有机硒化合物,除放射防护外,还具有许多重要的生物学意义。

更新日期:2020-11-02
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