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Diagnostics of skin features through 3D skin mapping based on electro-controlled deposition of conducting polymers onto metal-sebum modified surfaces and their possible applications in skin treatment
Analytica Chimica Acta ( IF 5.7 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.aca.2020.10.056
Xiaoxu Fu , Yi-Heng Cheong , Ashiq Ahamed , Chao Zhou , Chima Robert , Vida Krikstolaityte , Keith C. Gordon , Grzegorz Lisak

Analytical diagnostics of skin features was developed through application of portable and fast skin mapping based on electro-controlled deposition of conducting polymers onto metal-sebum modified surfaces. In this analytical diagnostic technique, the development of skin pattern is based on electropolymerization of conducting polymers within insulating barriers in skin stamp provided by natural sebum to monitor the 3D nature of various skin features. The recorded skin maps reach a μm-level resolution and are proved to be capable of recognition, enhancement, and reproduction of surface outlines of various skin topographies, subsequently assisting dermatological diagnosis. The technique can precisely record skin surface morphology and reflect the vertical dimension information within 10 min and is aimed to assist dermatologists working with patients suffering from skin diseases via recording or monitoring the skin surface conditions. Additionally, successful trials of loading and electro-controlled release of Cu2+ into/from the developed skin patterns reveals its potential to be also utilized for treatment of pathological skin conditions. Based on the developed analytical diagnostic technique, a well-designed 3D printed portable prototype device based on electrosynthesis of the conducting polymer powered by an ordinary battery (1.5 V) was tested and was found to have excellent performance in onsite 3D skin pattern reproduction from live human skin.

中文翻译:

基于导电聚合物在金属皮脂改性表面的电控沉积,通过 3D 皮肤映射诊断皮肤特征及其在皮肤治疗中的可能应用

皮肤特征的分析诊断是通过应用便携式和快速皮肤映射开发的,这种映射基于导电聚合物在金属皮脂改性表面上的电控沉积。在这种分析诊断技术中,皮肤图案的发展基于导电聚合物在天然皮脂提供的绝缘屏障内的电聚合,以监测各种皮肤特征的 3D 性质。记录的皮肤图达到微米级分辨率,并被证明能够识别、增强和再现各种皮肤形貌的表面轮廓,从而辅助皮肤​​病学诊断。该技术可以精确记录皮肤表面形态,并在10分钟内反映垂直尺寸信息,旨在通过记录或监测皮肤表面状况来帮助皮肤科医生与患有皮肤病的患者一起工作。此外,成功地将 Cu2+ 加载到/从开发的皮肤模式中释放出来的试验表明,它也有可能用于治疗病理性皮肤病。基于开发的分析诊断技术,对基于由普通电池 (1.5 V) 供电的导电聚合物电合成精心设计的 3D 打印便携式原型设备进行了测试,发现在现场 3D 皮肤图案再现方面具有出色的性能人的皮肤。
更新日期:2021-01-01
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