The receptor for advanced glycation end-products (receptor for AGEs, RAGE) is a pattern recognition receptor. The interaction of RAGE with its ligands, such as AGEs, S100 proteins, high mobility group box-1 (HMGB1), and lipopolysaccharides (LPS), is known to play a pivotal role in the propagation of immune responses and inflammatory reactions. The ligand-RAGE interaction elicits cellular responses, for example, in myeloid and lymphoid cells, through distinct pathways by activating NF-κB and Rac1/cdc42, which lead to cytokine production, cell migration, phagocytosis, maturation, and polarization. Recently, oxytocin, a peptide hormone and neuropeptide, was identified as a novel binding molecule for the RAGE; however, it cannot compete with the interaction of RAGE with other ligands or induce RAGE intracellular signaling. The RAGE transports oxytocin from the blood into the brain and regulates brain functions. In this review, we summarize the current understanding of glycation reaction, AGEs, and the RAGE-mediated biological responses as well as the physiological role of RAGE in immunity and social behaviors, particularly, maternal bonding.

晚期糖基化终产物的受体（AGEs，RAGE）是一种模式识别受体。众所周知，RAGE 与其配体（如 AGEs、S100 蛋白、高迁移率组框 1（HMGB1）和脂多糖（LPS））的相互作用在免疫反应和炎症反应的传播中起关键作用。配体-RAGE 相互作用通过激活 NF-κB 和 Rac1/cdc42 的不同途径引发细胞反应，例如，在骨髓和淋巴样细胞中，这导致细胞因子的产生、细胞迁移、吞噬作用、成熟和极化。最近，催产素，一种肽激素和神经肽，被确定为 RAGE 的一种新型结合分子。然而，它不能与 RAGE 与其他配体的相互作用竞争或诱导 RAGE 细胞内信号传导。RAGE 将催产素从血液输送到大脑并调节大脑功能。在这篇综述中，我们总结了目前对糖化反应、AGEs 和 RAGE 介导的生物反应的理解，以及 RAGE 在免疫和社会行为中的生理作用，特别是母体结合。