The use of electrospun membrane is of great importance to control the drug release rate and improve the remedial performance. In this work, etched halloysite nanotubes (eHNTs) loaded with Amoxicillin (AMX) were imbedded in poly(lactic acid) (PLA) solution and were electrospun to make nanocomposite fibrous web. The morphology, uniformity, and size of electrospun (PLA/eHNTs/AMX) nanocomposite fibers were evaluated by scanning electron microscopy (SEM). Fourier-transform infrared spectroscopy (FTIR), tensile test, and water contact angle measurement were employed, respectively, to investigate the chemical structure, mechanical properties, and surface wettability of samples. Results showed that the presence of eHNTs does not considerably change the morphology of nanofibrous mats but partly increases the fiber diameter from 382 nm for PLA, to 1143 nm for PLA/HNTs 5%; while the mechanical properties are modified owing to eHNTs’ high modulus. In current work, the modulus is equal to 12.57 MPa and has increased significantly compared to PLA nanofibers, 4.29 MPa. According to drug release test, eHNTs as adequate nanocarrier reduced initial burst release and induced sustained AMX release profiles over 168 h. The amount of AMX release after 148 h for PLA/eHNTs/AMX mat is decreased by 73% and 12.5% in comparison with PLA/AMX and PLA/HNTs/AMX mats, respectively.

Graphic abstract

中文翻译：

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引入电纺聚乳酸与蚀刻的埃洛石纳米管相结合，作为一种新型纳米纤维网，可控制阿莫西林的释放

电纺膜的使用对于控制药物释放速率和改善治疗效果非常重要。在这项工作中，将装载有阿莫西林（AMX）的蚀刻过的埃洛石纳米管（eHNT）嵌入到聚乳酸（PLA）溶液中，并进行电纺丝，制成纳米复合纤维网。通过扫描电子显微镜（SEM）评估了电纺（PLA / eHNTs / AMX）纳米复合纤维的形态，均匀性和尺寸。分别使用傅里叶变换红外光谱（FTIR），拉伸试验和水接触角测量来研究样品的化学结构，力学性能和表面润湿性。结果表明，eHNTs的存在不会显着改变纳米纤维毡的形态，但会部分增加PLA的纤维直径，从382 nm开始，对于5％的PLA / HNTs为1143 nm; 而由于eHNT的高模量，机械性能得到了改善。在目前的工作中，模量等于12.57 MPa，与PLA纳米纤维的4.29 MPa相比，模量显着增加。根据药物释放测试，作为适当的纳米载体的eHNT可以减少初始爆发释放并在168小时内诱导持续的AMX释放曲线。与PLA / AMX和PLA / HNTs / AMX垫相比，PLA / eHNT / AMX垫在148小时后释放的AMX量分别减少了73％和12.5％。作为适当的纳米载体的eHNTs在168小时内减少了初始爆发释放并诱导了AMX持续释放。与PLA / AMX和PLA / HNTs / AMX垫相比，PLA / eHNT / AMX垫在148小时后释放的AMX量分别减少了73％和12.5％。作为适当的纳米载体的eHNTs在168小时内减少了初始爆发释放并诱导了AMX持续释放。与PLA / AMX和PLA / HNTs / AMX垫相比，PLA / eHNT / AMX垫在148小时后释放的AMX量分别减少了73％和12.5％。

图形摘要