Abstract

Four new limonoids, toonayunnanaes F − I (1 − 4), and six known compounds (5 − 10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC₅₀ 38.45 ± 0.41 µM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.

Graphic Abstract

中文翻译：

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香椿树皮中的四种新柠檬苦素

摘要

四个新的柠檬苦素，toonayunnanaes的F - I（1  -  4），和六个已知化合物（5  -  10）从树皮中分离红椿。其结构经核磁共振和HRMS数据深入分析阐明，和单晶X射线衍射1。在氧杂环丁烷环部分1是柠檬苦素和其它天然产物的罕见。化合物1在脂多糖（LPS）活化的RAW 264.7巨噬细胞中表现出一氧化氮（NO）抑制作用，IC _50为38.45±0.41 µM。

图形摘要