Abstract

Methods for the synthesis of radiopaque tantalum-containing glass and glass-ceramics by doping 45S5 bioglass with tantalum oxide are presented. Bioactive glass has been obtained by pyrolysis of a mixture of organic precursors: tetraethoxysilane, tributyl phosphate, sodium oleate, and calcium oleate. Bioglass has been doped with tantalum oxide by three different methods. The mechanism of suppression of the biological activity of materials with an increase in the Ta₂O₅ content has been studied. The bioactivity of samples containing 1–40 wt % Ta₂O₅ has been evaluated in vitro using a model medium—an SBF solution. The samples have been studied by ³¹P NMR, XRD, SEM, and EDS. A decrease in the concentration of calcium in the glass phase due to the formation of insoluble CaTa₂O₆ crystals has been considered the major cause of the suppression of the bioactivity of glasses. Samples containing up to 10 wt % Ta₂O₅ can be used in modern medicine as materials that restore bone tissue. The radiopaque substance in the composition of the biomaterial makes it possible to monitor the process of bone tissue regeneration. Samples containing more than 20 wt % Ta₂O₅ failed in vitro tests. Due to the dissolution of one of the phases of glass-ceramics in a model solution, the prognosis for the use of such materials in vivo is unfavorable.

中文翻译：

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含钽的生物活性玻璃陶瓷：掺杂Ta 2 O 5抑制45S5生物玻璃生物活性的机制

摘要

提出了用45S5生物玻璃掺杂氧化钽合成不透射线的含钽玻璃和玻璃陶瓷的方法。通过将有机前体的混合物热解获得生物活性玻璃：四乙氧基硅烷，磷酸三丁酯，油酸钠和油酸钙。生物玻璃已通过三种不同的方法掺杂了氧化钽。研究了随着Ta ₂ O ₅含量的增加而抑制材料生物活性的机理。含有1–40 wt％Ta ₂ O ₅的样品的生物活性已使用模型培养基SBF溶液进行了体外评估。样本已被^31位研究P NMR，XRD，SEM和EDS。由于不溶性CaTa ₂ O ₆晶体的形成，玻璃相中钙浓度的降低被认为是抑制玻璃生物活性的主要原因。包含高达10 wt％Ta ₂ O _5的样品可以在现代医学中用作恢复骨骼组织的材料。生物材料组合物中的不透射线物质使监测骨组织再生过程成为可能。包含超过20 wt％Ta ₂ O _5的样品在体外测试中失败。由于玻璃陶瓷相之一溶解在模型溶液中，因此在体内使用这种材料的预后是不利的。