Abstract

A method for measurement of low-molecular weight compounds adsorption from solutions in liquefied gases and supercritical fluids based on the online coupling of high-pressure autoclave and supercritical fluid chromatograph has been proposed and tested. This method has been shown to be applicable to determine sorption capacity and to plot isotherms for adsorption of low-molecular weight compounds from solutions in supercritical carbon dioxide onto surface of silica xerogels and aerogels. The method provides the application of xerogels and aerogels as carriers for targeted drug delivery and controlled release.

中文翻译：

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使用超临界液相色谱在线监测超临界溶液对二氧化硅干凝胶和气凝胶的吸附

摘要

提出并测试了一种基于高压釜与超临界流体色谱仪在线耦合的低分子量化合物从液化气和超临界流体溶液中吸附的方法。已表明该方法可用于确定吸附能力并绘制等温线，以将低分子量化合物从超临界二氧化碳溶液吸附到硅胶干凝胶和气凝胶表面。该方法提供了干凝胶和气凝胶作为载体用于靶向药物递送和控释的应用。