Abstract A series of theophylline methyl 1,3,4-oxadiazole small molecules were obtained via cyclization of theophylline-7-acetohydrazide with different benzoic acids. The compounds ( IVa – j ) were synthesized and characterized by using conventional methods. The new compounds obtained were evaluated for their cytotoxic effect in three different cancer lines, the activity obtained varies depending upon the structure of a molecule. The compound ( IVb ) and ( IVf ) showed promising effect than other compounds of the series. Thus, these two derivatives have the potential for developing as anticancer agents.

中文翻译：

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茶碱甲基 1,3,4-恶二唑抗癌剂的合成及生物学评价

摘要 通过茶碱-7-乙酰肼与不同苯甲酸的环化反应，得到了一系列茶碱甲基1,3,4-恶二唑小分子化合物。使用常规方法合成和表征化合物（IVa-j）。在三种不同的癌症系中评估了获得的新化合物的细胞毒性作用，获得的活性取决于分子的结构。化合物(IVb)和(IVf)比该系列的其他化合物显示出有希望的效果。因此，这两种衍生物具有开发为抗癌剂的潜力。