Endometrial cancer remains the most common malignancy of the female genital system in developed countries. Tumor suppressor genes are responsible for controlling the cells fate in the cell cycle and preventing cancerogenesis. Gene expression affects cancer progression and is modulated by microRNAs defined as both tumor suppressors and oncogenes. These molecules indirectly regulate multiple processes like cell proliferation, differentiation and apoptosis. The aim of this study was to analyze miRNAs expression that can regulate the activity of tumor suppressor genes related to the cell cycle in patients with endometrioid endometrial cancer. The study group consisted of 12 samples that met the inclusion criteria from a total of 48 obtained. The 12 samples were used to analyze microRNA expression. Complementary miRNAs were identified using TargetScan Database and statistical analysis. MicroRNAs were determined for the tumor suppressor genes: CYR61, WT1, TSPYL5, HNRNPA0, BCL2L1 and BAK1. All the miRNAs were complementary to the described target genes based on TargetScan Database. There were five miRNAs differentially expressed that can regulate tumor suppressor genes related to the cell cycle. The distinguished miRNAs: mir-340-3p, mir-1236-5p, mir-874-3p, mir-873-5p.2 and mir-548-5p were differentially expressed in endometrial cancer in comparison to the control. Among the distinguished miRNAs, the most promising is mir-874-3p, which may have an important role in endometrial adenocarcinoma proliferation.

子宫内膜癌仍然是发达国家女性生殖系统最常见的恶性肿瘤。肿瘤抑制基因负责控制细胞周期中的细胞命运并防止癌症发生。基因表达影响癌症进展，并受定义为肿瘤抑制基因和癌基因的 microRNA 调节。这些分子间接调节细胞增殖、分化和凋亡等多种过程。本研究的目的是分析可以调节与子宫内膜样子宫内膜癌患者细胞周期相关的抑癌基因活性的miRNAs表达。研究组由 12 个符合纳入标准的样本组成，共 48 个样本。12 个样品用于分析 microRNA 表达。使用 TargetScan 数据库和统计分析鉴定了互补的 miRNA。确定了肿瘤抑制基因的微小 RNA：CYR61、WT1、TSPYL5、HNRNPA0、BCL2L1 和 BAK1。所有 miRNA 都与基于 TargetScan 数据库的所述靶基因互补。有5个miRNA差异表达，可以调节与细胞周期相关的抑癌基因。与对照相比，mir-340-3p、mir-1236-5p、mir-874-3p、mir-873-5p.2和mir-548-5p在子宫内膜癌中差异表达。在杰出的 miRNA 中，最有希望的是 mir-874-3p，它可能在子宫内膜腺癌的增殖中起重要作用。所有 miRNA 都与基于 TargetScan 数据库的所述靶基因互补。有5个miRNA差异表达，可以调节与细胞周期相关的抑癌基因。与对照相比，mir-340-3p、mir-1236-5p、mir-874-3p、mir-873-5p.2和mir-548-5p在子宫内膜癌中差异表达。在杰出的 miRNA 中，最有希望的是 mir-874-3p，它可能在子宫内膜腺癌的增殖中起重要作用。所有 miRNA 都与基于 TargetScan 数据库的所述靶基因互补。有5个miRNA差异表达，可以调节与细胞周期相关的抑癌基因。与对照相比，mir-340-3p、mir-1236-5p、mir-874-3p、mir-873-5p.2和mir-548-5p在子宫内膜癌中差异表达。在杰出的 miRNA 中，最有希望的是 mir-874-3p，它可能在子宫内膜腺癌的增殖中起重要作用。与对照相比，2 和 mir-548-5p 在子宫内膜癌中差异表达。在杰出的 miRNA 中，最有希望的是 mir-874-3p，它可能在子宫内膜腺癌的增殖中起重要作用。与对照相比，2 和 mir-548-5p 在子宫内膜癌中差异表达。在杰出的 miRNA 中，最有希望的是 mir-874-3p，它可能在子宫内膜腺癌的增殖中起重要作用。