Abstract

The heat shock protein Hsp70 is involved in cell defense from various types of stress, including the proteotoxic stress, which occurs during the development of many neurodegenerative diseases. This work presents data on the detection of small molecules, derivatives of indolyl- and pyrrolylazines, which can activate the synthesis of Hsp70 and cause its accumulation in the cell. The toxicity level of the new Hsp70 synthesis inducers was evaluated, and the safety of these compounds was demonstrated in experiments on SH-SY5Y neuroblastoma cell line. Derivatives of indolyl- and pyrrolylazines presented in this work can be potential therapeutic agents in models of neurodegenerative diseases that should be studied in more detail.

中文翻译：

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吲哚基和吡咯烷基嗪衍生物导致Sh-Sy5Y人神经母细胞瘤细胞中热休克蛋白Hsp70的积累

摘要

热休克蛋白Hsp70参与细胞防御各种类型的应激，包括蛋白毒性应激，这种应激发生在许多神经退行性疾病的发展过程中。这项工作提供了有关检测小分子，吲哚基和吡咯烷基嗪衍生物的数据，这些分子可以激活Hsp70的合成并引起其在细胞中的积累。评价了新的Hsp70合成诱导剂的毒性水平，并在SH-SY5Y神经母细胞瘤细胞系的实验中证明了这些化合物的安全性。在这项工作中提出的吲哚基和吡咯烷基嗪的衍生物可能是神经退行性疾病模型中的潜在治疗剂，应进行更详细的研究。