Persons with their eye closed and without any means of communication is said to be in a completely locked-in state (CLIS) while when they could still open their eyes actively or passively and have some means of communication are said to be in locked-in state (LIS). Two patients in CLIS without any means of communication, and one patient in the transition from LIS to CLIS with means of communication, who have Amyotrophic Lateral Sclerosis were followed at a regular interval for more than 1 year. During each visit, resting-state EEG was recorded before the brain–computer interface (BCI) based communication sessions. The resting-state EEG of the patients was analyzed to elucidate the evolution of their EEG spectrum over time with the disease’s progression to provide future BCI-research with the relevant information to classify changes in EEG evolution. Comparison of power spectral density (PSD) of these patients revealed a significant difference in the PSD’s of patients in CLIS without any means of communication and the patient in the transition from LIS to CLIS with means of communication. The EEG of patients without any means of communication is devoid of alpha, beta, and higher frequencies than the patient in transition who still had means of communication. The results show that the change in the EEG frequency spectrum may serve as an indicator of the communication ability of such patients.

闭上眼睛且没有任何通讯手段的人被称为处于完全锁定状态（CLIS），而当他们仍然可以主动或被动地睁开眼睛并有一些通讯手段时被称为处于锁定状态状态（LIS）。两名患有肌萎缩侧索硬化症的 CLIS 患者没有任何沟通手段，以及一名从 LIS 过渡到 CLIS 有沟通手段的患者，均定期随访超过 1 年。在每次访问期间，在基于脑机接口（BCI）的通信会话之前记录静息态脑电图。对患者的静息态脑电图进行分析，以阐明其脑电图谱随疾病进展而随时间的演变，为未来的脑机接口研究提供对脑电图演变变化进行分类的相关信息。这些患者的功率谱密度 (PSD) 比较显示，没有任何通信手段的 CLIS 患者和从 LIS 过渡到有通信手段的 CLIS 患者的 PSD 存在显着差异。没有任何通讯手段的患者的脑电图缺乏α、β，并且比仍然有通讯手段的过渡期患者的频率更高。结果表明，脑电图频谱的变化可以作为此类患者沟通能力的指标。